Detailed information of TA system TA063235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2061634..2062238
• Replicon: chromosome
• Accession: NZ_CP015600
• Organism: Pseudomonas antarctica strain PAMC 27494

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A7J50_RS09585
• Protein ID: WP_064451579.1
• Coordinates: 2061634..2061822 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A172YZ10
• Locus tag: A7J50_RS09590
• Protein ID: WP_064451580.1
• Coordinates: 2061834..2062238 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7J50_RS09560	2056849..2058033	+	1185	WP_064451575.1	c-type cytochrome biogenesis protein CcmI	-
A7J50_RS09565	2058049..2058444	+	396	WP_064451576.1	hypothetical protein	-
A7J50_RS09570	2058878..2059456	+	579	WP_064454888.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
A7J50_RS09575	2059607..2060302	-	696	WP_064451577.1	ArsR family transcriptional regulator	-
A7J50_RS09580	2060378..2061499	+	1122	WP_064451578.1	cytochrome P450	-
A7J50_RS09585	2061634..2061822	+	189	WP_064451579.1	type II toxin-antitoxin system HicA family toxin	Toxin
A7J50_RS09590	2061834..2062238	+	405	WP_064451580.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A7J50_RS09595	2062245..2063441	-	1197	WP_082895853.1	MFS transporter	-
A7J50_RS09600	2063620..2064234	+	615	WP_064454889.1	hypothetical protein	-
A7J50_RS09605	2064368..2065372	-	1005	WP_064451582.1	sulfate ABC transporter substrate-binding protein	-
A7J50_RS09610	2065478..2066302	-	825	WP_064451583.1	ion transporter	-
A7J50_RS09615	2066334..2067206	-	873	WP_064451584.1	urea transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7134.36 Da
• Isoelectric Point: 11.5760

>T63235 WP_064451579.1 NZ_CP015600:2061634-2061822 [Pseudomonas antarctica]
VQSRLLIKALQEAGWVLDRVTGSHHIFTHRYSPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Nucleotide

• Length: 189 bp

>T63235 NZ_CP015600:2061634-2061822 [Pseudomonas antarctica]
GTGCAAAGCAGGTTATTGATCAAGGCGCTGCAAGAGGCGGGCTGGGTGCTGGATAGGGTCACGGGCAGTCATCACATTTT
CACTCACCGCTATAGCCCGTACACGATCCCGGTGCCGCACCCCAAGAAGGACCTGCCGTTGGGCACGGTCAGAAGTATCA
GGAAGCGCGCCGGGCTGTTTCAGTTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14726.73 Da
• Isoelectric Point: 4.7437

>AT63235 WP_064451580.1 NZ_CP015600:2061834-2062238 [Pseudomonas antarctica]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGVIPMPTSVAHHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT63235 NZ_CP015600:2061834-2062238 [Pseudomonas antarctica]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTCACCGCCACCGGTATTCAGATCCCCGATATTCCAGGTGCTGT
CACCGCCGGGGACAGTTTTGAAGAGGCGTACAACGCCGCTGTGGAAGTCGCGCACATCATGCTGCAAGAGATCGCGGCAG
AGGGGGGCGTGATTCCGATGCCAACCTCAGTGGCCCATCATCATGCCCACGAAGACTACGCGGGGATGGGCTGGGGCATG
CTGGAGTTGGACATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTCATTCAGCGCAT
CGACCGCTATGTGCGCGAGCACAAGGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCGTTGGAGAAGTTGGTGCGTT
CTTAG

Structures

Antitoxin

• AlphaFold DB: A0A172YZ10