Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 97560..98221 Replicon plasmid pMYC1
Accession NZ_CP015597
Organism Mycobacterium sp. YC-RL4

Toxin (Protein)


Gene name vapC Uniprot ID A0A172UWE1
Locus tag A7U43_RS28200 Protein ID WP_068004105.1
Coordinates 97560..97964 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A172UWP0
Locus tag A7U43_RS28205 Protein ID WP_068004448.1
Coordinates 97961..98221 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U43_RS28180 93216..94862 + 1647 WP_068004098.1 serine/threonine protein kinase -
A7U43_RS29920 94979..95155 + 177 WP_156526210.1 hypothetical protein -
A7U43_RS28185 95161..96102 - 942 WP_068004446.1 non-homologous end-joining DNA ligase -
A7U43_RS28190 96248..97180 - 933 WP_068004101.1 discoidin domain-containing protein -
A7U43_RS28195 97183..97563 - 381 WP_068004103.1 hypothetical protein -
A7U43_RS28200 97560..97964 - 405 WP_068004105.1 PIN domain-containing protein Toxin
A7U43_RS28205 97961..98221 - 261 WP_068004448.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A7U43_RS28210 98383..98718 + 336 WP_156526211.1 hypothetical protein -
A7U43_RS28215 99225..99545 - 321 WP_068004111.1 hypothetical protein -
A7U43_RS28220 99593..100957 - 1365 WP_068004113.1 cutinase family protein -
A7U43_RS28225 100954..101670 - 717 WP_068004119.1 hypothetical protein -
A7U43_RS28230 102243..102443 + 201 WP_068004121.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..252568 252568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 13903.85 Da        Isoelectric Point: 5.8106

>T63231 WP_068004105.1 NZ_CP015597:c97964-97560 [Mycobacterium sp. YC-RL4]
VIYLDPTALMKLIDEAPESAALTAYLSAHTDTRWITCALSRAELLRAMAALPPDATGHAHHVLAGLDTVAVTERLLDAAV
ALTPSPARTVDALHIASALSAGPRLRTLVTYDPQLADAAAGHHITTVSPGGESP

Download         Length: 405 bp

>T63231 NZ_CP015597:c97964-97560 [Mycobacterium sp. YC-RL4]
GTGATCTATCTCGACCCCACCGCCCTCATGAAACTCATCGACGAAGCACCCGAATCCGCCGCCCTAACCGCATACCTCAG
CGCGCACACCGACACCCGATGGATCACCTGCGCGCTGTCACGAGCCGAGCTGCTCCGCGCCATGGCCGCGCTACCTCCAG
ACGCCACCGGGCATGCCCACCACGTCCTGGCCGGACTCGACACCGTGGCCGTCACCGAGCGCCTCCTCGACGCCGCCGTG
GCGCTTACCCCCAGCCCTGCACGCACCGTCGACGCACTGCACATCGCATCGGCCCTGAGCGCCGGACCACGACTGCGCAC
CCTCGTCACCTACGACCCCCAACTCGCCGACGCCGCAGCCGGCCATCACATCACCACCGTCAGCCCCGGAGGGGAATCAC
CGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9509.81 Da        Isoelectric Point: 10.0884

>AT63231 WP_068004448.1 NZ_CP015597:c98221-97961 [Mycobacterium sp. YC-RL4]
MKSYGVRELRQNAAMVLREVAAGETVEITNNGHPVAQMIPASYDPWTALIASKEVTAARSSVTDILKRPPRPYRQTTSTA
VPRDDR

Download         Length: 261 bp

>AT63231 NZ_CP015597:c98221-97961 [Mycobacterium sp. YC-RL4]
ATGAAGAGCTACGGTGTCCGTGAACTGCGCCAGAATGCAGCCATGGTCCTACGCGAGGTGGCCGCCGGCGAAACCGTCGA
GATCACCAACAACGGACACCCCGTCGCGCAGATGATCCCCGCCTCCTACGACCCCTGGACCGCGCTTATCGCCAGCAAGG
AAGTCACCGCCGCGCGCAGCAGCGTCACCGACATCCTCAAACGCCCACCCCGCCCGTACCGCCAGACCACCAGCACCGCC
GTCCCACGGGACGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172UWE1

Antitoxin

Source ID Structure
AlphaFold DB A0A172UWP0

References