Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 86714..87255 Replicon plasmid pMYC1
Accession NZ_CP015597
Organism Mycobacterium sp. YC-RL4

Toxin (Protein)


Gene name relE Uniprot ID A0A172UWI4
Locus tag A7U43_RS28155 Protein ID WP_068004090.1
Coordinates 86998..87255 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A172UWM4
Locus tag A7U43_RS28150 Protein ID WP_068004441.1
Coordinates 86714..87001 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U43_RS28135 82266..84695 - 2430 WP_068004438.1 hypothetical protein -
A7U43_RS28140 85400..86002 - 603 WP_068004086.1 hypothetical protein -
A7U43_RS28145 86037..86558 - 522 WP_068004088.1 hypothetical protein -
A7U43_RS28150 86714..87001 + 288 WP_068004441.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7U43_RS28155 86998..87255 + 258 WP_068004090.1 Txe/YoeB family addiction module toxin Toxin
A7U43_RS29490 87287..87505 - 219 Protein_100 type II toxin-antitoxin system prevent-host-death family antitoxin -
A7U43_RS28160 87730..88080 - 351 WP_068004444.1 hypothetical protein -
A7U43_RS28165 88558..89964 + 1407 WP_068004093.1 hypothetical protein -
A7U43_RS28170 90515..91183 - 669 Protein_103 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..252568 252568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10174.49 Da        Isoelectric Point: 9.3924

>T63230 WP_068004090.1 NZ_CP015597:86998-87255 [Mycobacterium sp. YC-RL4]
VRSIHFDPDGWDDFLYWLATDRKTARRITRLIAEIQRDPFNGIGKPEPLKGDLSGYWSRRIDDEHRLVYRADANEVKILK
ARYHY

Download         Length: 258 bp

>T63230 NZ_CP015597:86998-87255 [Mycobacterium sp. YC-RL4]
GTGAGAAGCATCCATTTCGACCCAGACGGATGGGACGACTTCCTGTACTGGCTGGCCACCGATCGGAAAACGGCGCGCAG
GATCACGAGGCTGATCGCAGAGATTCAACGAGATCCGTTCAACGGCATCGGGAAGCCGGAACCGTTGAAGGGCGACCTCT
CCGGGTACTGGTCGCGGCGCATCGACGACGAGCACCGTCTGGTGTACCGGGCCGACGCCAATGAGGTGAAGATCCTGAAA
GCCCGCTACCACTACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10536.61 Da        Isoelectric Point: 4.3016

>AT63230 WP_068004441.1 NZ_CP015597:86714-87001 [Mycobacterium sp. YC-RL4]
MSISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSADDYDSWQETVYLLRSPENARRLMEAVARDKGSQSPNSVDH
ATTIEELEEMSGGQA

Download         Length: 288 bp

>AT63230 NZ_CP015597:86714-87001 [Mycobacterium sp. YC-RL4]
ATGTCTATCAGCGCAAGCGAAGCACGTCAGCGGCTGTTTCCCCTGCTGGAGCAAGTCAATACCGACCACGAGCCCGTCCG
GATTACGTCCAAGGCCGGTGACGCAGTGTTGATGTCAGCGGACGATTACGACTCGTGGCAGGAGACCGTCTACCTGCTGC
GATCTCCTGAGAACGCACGGCGGCTGATGGAGGCCGTCGCCCGAGACAAAGGTTCTCAATCTCCTAATTCGGTGGATCAC
GCGACGACGATCGAGGAACTCGAGGAGATGTCCGGCGGCCAGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172UWI4

Antitoxin

Source ID Structure
AlphaFold DB A0A172UWM4

References