Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/-
Location 2174414..2175047 Replicon chromosome
Accession NZ_CP015594
Organism Acinetobacter sp. NCu2D-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A172YQR9
Locus tag A3K93_RS10395 Protein ID WP_067731168.1
Coordinates 2174414..2174797 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A172YR14
Locus tag A3K93_RS10400 Protein ID WP_067731169.1
Coordinates 2174790..2175047 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3K93_RS10380 2169880..2172066 - 2187 WP_067731165.1 TRAP transporter large permease subunit -
A3K93_RS10385 2172224..2172805 - 582 WP_067731166.1 rhombosortase -
A3K93_RS10390 2172886..2173917 - 1032 WP_067731167.1 hypothetical protein -
A3K93_RS10395 2174414..2174797 - 384 WP_067731168.1 hypothetical protein Toxin
A3K93_RS10400 2174790..2175047 - 258 WP_067731169.1 succinate dehydrogenase assembly factor 2 Antitoxin
A3K93_RS10405 2175232..2176404 + 1173 WP_067731170.1 acyl-CoA dehydrogenase family protein -
A3K93_RS10410 2176462..2177952 - 1491 WP_067731171.1 NAD(P)/FAD-dependent oxidoreductase -
A3K93_RS10415 2178159..2178524 - 366 WP_004691290.1 50S ribosomal protein L17 -
A3K93_RS10420 2178543..2179550 - 1008 WP_004869497.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(10-80)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 15295.30 Da        Isoelectric Point: 9.1426

>T63224 WP_067731168.1 NZ_CP015594:c2174797-2174414 [Acinetobacter sp. NCu2D-2]
MDSRCFKLKRSWFALGFQLLIFIILMFVLYQLVPLWLWAMCVIAGLVMYQLFYQKSPKIDQFEYLDGREWSISCQDQVKR
VEISHVIDHQVYIVVYFRHAKARPLLIWCDQLPMQQWKALKAFTQLA

Download         Length: 384 bp

>T63224 NZ_CP015594:c2174797-2174414 [Acinetobacter sp. NCu2D-2]
ATGGATAGTCGCTGTTTTAAGCTGAAACGCAGTTGGTTTGCGCTTGGGTTTCAGCTTTTGATTTTTATTATATTGATGTT
TGTATTGTACCAGTTGGTGCCACTGTGGTTATGGGCGATGTGTGTGATCGCAGGACTGGTGATGTATCAACTGTTTTATC
AAAAATCACCTAAGATTGATCAGTTTGAATATTTGGATGGACGGGAATGGAGTATTTCTTGTCAAGACCAAGTCAAACGG
GTTGAGATTAGCCATGTGATCGATCATCAAGTGTATATCGTGGTGTATTTTCGTCATGCTAAAGCACGTCCACTCTTGAT
TTGGTGTGATCAATTGCCTATGCAACAATGGAAAGCCTTAAAAGCATTTACCCAGCTTGCTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10155.59 Da        Isoelectric Point: 4.7132

>AT63224 WP_067731169.1 NZ_CP015594:c2175047-2174790 [Acinetobacter sp. NCu2D-2]
MTDDISLEERKVIYRARRGLKEIDVYFDPYVKNHYLSASAEEKQMFADLVAQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Download         Length: 258 bp

>AT63224 NZ_CP015594:c2175047-2174790 [Acinetobacter sp. NCu2D-2]
ATGACTGATGACATCAGCCTAGAAGAACGCAAAGTCATTTACCGCGCACGTCGTGGTTTAAAAGAAATTGATGTATATTT
TGATCCGTATGTGAAAAATCACTATTTGTCGGCATCTGCGGAAGAAAAACAGATGTTTGCAGATTTAGTTGCACAAGAAG
ATCCAGATTTACTCGATTGGTTTATGGAAGTCTCTGAGCCACCACGTCCTGAATTAAAAGATTTTATTAAGAAGTTGAAA
TTTTACGTTCATGGATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A172YQR9


Antitoxin

Source ID Structure
AlphaFold DB A0A172YR14

References