Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 55058..55701 Replicon plasmid 2
Accession NZ_CP015586
Organism Roseomonas gilardii strain U14-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RGI145_RS24305 Protein ID WP_075801100.1
Coordinates 55291..55701 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RGI145_RS24300 Protein ID WP_075801099.1
Coordinates 55058..55294 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGI145_RS24280 50258..51148 + 891 WP_075801095.1 dihydrodipicolinate synthase family protein -
RGI145_RS24285 51222..51779 - 558 WP_075801096.1 tyrosine-type recombinase/integrase -
RGI145_RS24290 51853..53127 - 1275 WP_075801097.1 hypothetical protein -
RGI145_RS24295 53114..54604 - 1491 WP_075801098.1 AAA family ATPase -
RGI145_RS24300 55058..55294 + 237 WP_075801099.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RGI145_RS24305 55291..55701 + 411 WP_075801100.1 PIN domain-containing protein Toxin
RGI145_RS24310 55698..56801 + 1104 WP_075801101.1 site-specific integrase -
RGI145_RS24315 56879..57607 + 729 WP_075801102.1 hypothetical protein -
RGI145_RS24320 57716..58123 + 408 WP_075801103.1 hypothetical protein -
RGI145_RS24325 58210..58740 + 531 Protein_59 transposase -
RGI145_RS25535 58909..59637 - 729 WP_167668435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64339 64339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)

Antitoxin

SpoVT-AbrB domain

(5-36)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14688.90 Da        Isoelectric Point: 5.8580

>T63220 WP_075801100.1 NZ_CP015586:55291-55701 [Roseomonas gilardii]
MSRPFLDTNILLYAALQPDPRSETARGLLARGGLVSVQVLNEFTAVARRKLRRPWPEVRQALAAIRTLCPAAPRPLTVAT
HDAAIGLAERLGYTIDDALILASALEAGCDTLFSEDLQDGQVVEGQLTIRNPFAAP

Download         Length: 411 bp

>T63220 NZ_CP015586:55291-55701 [Roseomonas gilardii]
ATGAGCCGGCCCTTCCTCGACACCAACATCCTGCTCTACGCCGCCCTGCAGCCGGATCCGCGCTCCGAGACGGCCCGCGG
CCTCCTGGCCCGGGGCGGCCTGGTCAGCGTCCAGGTGCTCAACGAGTTCACCGCCGTCGCCCGCCGCAAGCTGCGCCGGC
CCTGGCCCGAGGTCAGGCAGGCGCTGGCCGCCATCCGGACCCTCTGTCCGGCGGCGCCACGGCCGCTGACCGTCGCGACG
CATGATGCGGCCATCGGGCTGGCGGAAAGGCTGGGCTACACGATTGACGATGCCCTGATCCTGGCCTCGGCCCTGGAGGC
TGGCTGCGACACGCTCTTCTCCGAGGATCTGCAGGACGGGCAGGTGGTCGAAGGGCAACTGACCATCCGCAACCCCTTCG
CCGCGCCATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8738.77 Da        Isoelectric Point: 5.7135

>AT63220 WP_075801099.1 NZ_CP015586:55058-55294 [Roseomonas gilardii]
MQVSRWGNSLAVRLPAAVVEALGLREGDEVAIEVADPHTFRVARDRRRDEAIEALRGLGWHLPDGFRFSREEANERGG

Download         Length: 237 bp

>AT63220 NZ_CP015586:55058-55294 [Roseomonas gilardii]
ATGCAGGTCAGCCGCTGGGGCAACAGCCTCGCCGTCCGCCTCCCCGCCGCCGTGGTGGAGGCTTTGGGCCTGCGCGAGGG
CGACGAGGTCGCCATCGAGGTGGCCGACCCCCACACCTTCCGCGTGGCCCGCGACCGCCGCCGCGACGAGGCGATCGAGG
CACTGCGCGGTCTCGGCTGGCACCTGCCCGACGGCTTCCGCTTCTCGCGCGAGGAAGCCAACGAGCGCGGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References