Detailed information of TA system TA063215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 750950..751728
• Replicon: chromosome
• Accession: NZ_CP015581
• Organism: Tatumella citrea strain ATCC 39140

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: A7K99_RS03585
• Protein ID: WP_087487337.1
• Coordinates: 750950..751438 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A1Y0L5F0
• Locus tag: A7K99_RS03590
• Protein ID: WP_038917748.1
• Coordinates: 751435..751728 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7K99_RS03570	747091..748500	-	1410	WP_087487335.1	N-6 DNA methylase	-
A7K99_RS03575	749011..749490	+	480	Protein_693	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
A7K99_RS03580	749753..750856	-	1104	WP_087487336.1	hypothetical protein	-
A7K99_RS03585	750950..751438	-	489	WP_087487337.1	GNAT family N-acetyltransferase	Toxin
A7K99_RS03590	751435..751728	-	294	WP_038917748.1	DUF1778 domain-containing protein	Antitoxin
A7K99_RS03595	752709..753482	+	774	WP_087487338.1	amino acid ABC transporter substrate-binding protein	-
A7K99_RS03600	753620..755113	-	1494	WP_087487339.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (73-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17487.35 Da
• Isoelectric Point: 6.6960

>T63215 WP_087487337.1 NZ_CP015581:c751438-750950 [Tatumella citrea]
MISAPEPLRAEHVLSSFCCGVESMDNWLKLRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVAMNSAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVCDAGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SF

Nucleotide

• Length: 489 bp

>T63215 NZ_CP015581:c751438-750950 [Tatumella citrea]
ATGATTTCCGCCCCTGAGCCACTCCGTGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTAAAACTACGGGCGATGAAAAATCAGGTCACTGGAGCATCACGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGTGCTGTAGCAATGAATTCAGCTCCCGGACGTTTTCGCCGAAATATGCCCGATCCTATC
CCGGTCGTGGTGTTGGGGAGGTTGGCTGTGGATACGTCATTGCATGGTCAAGGTGTTGGCCGTGCTCTGGTATGTGATGC
TGGGCTAAGAGTGATTCAGGTTGCTGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGCTGTCTGATGAGGCACGGG
AATTTTATCTACGGGTGGGGTTTGAACCTTCGCCGATAGATCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTTGGG
AGTTTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10872.44 Da
• Isoelectric Point: 10.1968

>AT63215 WP_038917748.1 NZ_CP015581:c751728-751435 [Tatumella citrea]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPSPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT63215 NZ_CP015581:c751728-751435 [Tatumella citrea]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACACTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCTAAGGCCAGAGGAAAAAATCGTACCGATTTTGTCCTTGAAGCTGCTCGCGCTGCAGCGGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCTGACGCTTATCAGGAATTCCTTGCCCGTTTGGATCAAGCTCCCTCTCCGAAT
GCCGCGCTGCGTAAAACCATGCAAACACCTGCACCGTGGGAACAGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Y0L5F0