Detailed information of TA system TA063210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 751277..752055
• Replicon: chromosome
• Accession: NZ_CP015579
• Organism: Tatumella citrea strain DSM 13699

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: A7K98_RS03590
• Protein ID: WP_087487337.1
• Coordinates: 751277..751765 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A1Y0L5F0
• Locus tag: A7K98_RS03595
• Protein ID: WP_038917748.1
• Coordinates: 751762..752055 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7K98_RS03575	747418..748827	-	1410	WP_087487335.1	N-6 DNA methylase	-
A7K98_RS03580	749338..749817	+	480	Protein_694	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
A7K98_RS03585	750080..751183	-	1104	WP_087487336.1	hypothetical protein	-
A7K98_RS03590	751277..751765	-	489	WP_087487337.1	GNAT family N-acetyltransferase	Toxin
A7K98_RS03595	751762..752055	-	294	WP_038917748.1	DUF1778 domain-containing protein	Antitoxin
A7K98_RS03600	753036..753809	+	774	WP_087487338.1	amino acid ABC transporter substrate-binding protein	-
A7K98_RS03605	753947..755440	-	1494	WP_087487339.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (73-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17487.35 Da
• Isoelectric Point: 6.6960

>T63210 WP_087487337.1 NZ_CP015579:c751765-751277 [Tatumella citrea]
MISAPEPLRAEHVLSSFCCGVESMDNWLKLRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVAMNSAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVCDAGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SF

Nucleotide

• Length: 489 bp

>T63210 NZ_CP015579:c751765-751277 [Tatumella citrea]
ATGATTTCCGCCCCTGAGCCACTCCGTGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTAAAACTACGGGCGATGAAAAATCAGGTCACTGGAGCATCACGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGTGCTGTAGCAATGAATTCAGCTCCCGGACGTTTTCGCCGAAATATGCCCGATCCTATC
CCGGTCGTGGTGTTGGGGAGGTTGGCTGTGGATACGTCATTGCATGGTCAAGGTGTTGGCCGTGCTCTGGTATGTGATGC
TGGGCTAAGAGTGATTCAGGTTGCTGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGCTGTCTGATGAGGCACGGG
AATTTTATCTACGGGTGGGGTTTGAACCTTCGCCGATAGATCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTTGGG
AGTTTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10872.44 Da
• Isoelectric Point: 10.1968

>AT63210 WP_038917748.1 NZ_CP015579:c752055-751762 [Tatumella citrea]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPSPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT63210 NZ_CP015579:c752055-751762 [Tatumella citrea]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACACTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCTAAGGCCAGAGGAAAAAATCGTACCGATTTTGTCCTTGAAGCTGCTCGCGCTGCAGCGGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCTGACGCTTATCAGGAATTCCTTGCCCGTTTGGATCAAGCTCCCTCTCCGAAT
GCCGCGCTGCGTAAAACCATGCAAACACCTGCACCGTGGGAACAGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Y0L5F0