63189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1014613..1015108 Replicon chromosome
Accession NZ_CP015557
Organism Streptococcus suis strain DN13

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8KF86
Locus tag A6M16_RS05085 Protein ID WP_024395851.1
Coordinates 1014842..1015108 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag A6M16_RS05080 Protein ID WP_015646833.1
Coordinates 1014613..1014852 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6M16_RS05055 1009942..1011108 + 1167 WP_024395848.1 ATP-grasp domain-containing protein -
A6M16_RS05060 1011248..1011388 + 141 WP_032536643.1 hypothetical protein -
A6M16_RS05065 1011401..1011790 + 390 WP_024395849.1 NisI/SpaI family lantibiotic immunity lipoprotein -
A6M16_RS05070 1011799..1012551 + 753 WP_015646831.1 ABC transporter ATP-binding protein -
A6M16_RS05075 1012552..1014522 + 1971 WP_063725261.1 FtsX-like permease family protein -
A6M16_RS05080 1014613..1014852 + 240 WP_015646833.1 hypothetical protein Antitoxin
A6M16_RS05085 1014842..1015108 + 267 WP_024395851.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6M16_RS05090 1015150..1015815 + 666 WP_024395852.1 response regulator transcription factor -
A6M16_RS05095 1015812..1016753 + 942 WP_024390381.1 sensor histidine kinase -
A6M16_RS05100 1016830..1018338 + 1509 WP_024395853.1 phosphoglucomutase -
A6M16_RS05105 1018401..1019471 - 1071 WP_024390379.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10272.03 Da        Isoelectric Point: 10.4518

>T63189 WP_024395851.1 NZ_CP015557:1014842-1015108 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALIANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T63189 NZ_CP015557:1014842-1015108 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGATGGATAAAACTGCTGCAAGTTTGATTTT
GCGGTATCTTTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGATTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT63189 WP_015646833.1 NZ_CP015557:1014613-1014852 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT63189 NZ_CP015557:1014613-1014852 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGATAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8KF86

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References