Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1651696..1652207 Replicon chromosome
Accession NZ_CP015553
Organism Staphylococcus carnosus strain TMW 2.1596

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag A2I68_RS08485 Protein ID WP_015900832.1
Coordinates 1651696..1651902 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag A2I68_RS08490 Protein ID WP_015900833.1
Coordinates 1651914..1652207 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I68_RS08465 (A2I68_08295) 1647669..1648886 + 1218 WP_046100522.1 FtsW/RodA/SpoVE family cell cycle protein -
A2I68_RS08470 1648958..1649098 - 141 WP_167313208.1 Lmo0850 family protein -
A2I68_RS08475 (A2I68_08300) 1649174..1651375 - 2202 WP_046100521.1 heavy metal translocating P-type ATPase -
A2I68_RS08480 (A2I68_08305) 1651472..1651681 - 210 WP_046100520.1 copper ion binding protein -
A2I68_RS08485 (A2I68_08310) 1651696..1651902 - 207 WP_015900832.1 heavy metal-associated domain-containing protein Toxin
A2I68_RS08490 (A2I68_08315) 1651914..1652207 - 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
A2I68_RS08495 (A2I68_08320) 1652372..1653853 + 1482 WP_046100519.1 cardiolipin synthase -
A2I68_RS08500 (A2I68_08325) 1653878..1654525 + 648 WP_046100518.1 HD domain-containing protein -
A2I68_RS08505 (A2I68_08330) 1654616..1655128 - 513 WP_046100517.1 GNAT family N-acetyltransferase -
A2I68_RS08510 (A2I68_08335) 1655239..1656108 - 870 WP_015900837.1 membrane protein insertase YidC -
A2I68_RS08515 (A2I68_08340) 1656197..1656835 - 639 WP_046100516.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T63184 WP_015900832.1 NZ_CP015553:c1651902-1651696 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T63184 NZ_CP015553:c1651902-1651696 [Staphylococcus carnosus]
ATGCAAAATAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTGCATCAACATCTTATAGAAAT
GACAGGTGTATCTGCAGTGCAAGTGGATATGGATTCAAATGAAGTCAGAATCAGTTATGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCAGGTTATCAAATATTAAATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT63184 WP_015900833.1 NZ_CP015553:c1652207-1651914 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT63184 NZ_CP015553:c1652207-1651914 [Staphylococcus carnosus]
ATGACCGAAAATGATAAAGCGCACCATTCAGAACAAATCAAATCCAACTTGAAAGCACGACTCAATCGAATTGAAGGACA
AGTCAGAGCAATTAACCGAATGATTGAAGAGGATGTATATTGTGATGATGTACTCACACAAATCCGTGCAACACGTTCAG
CTTTGAACAGTGTGGCAGTACGATTGCTTGATCATCACATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCGATGGAAGAATTACTTGTTACCGTTCAAAAATTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References