63180

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 976235..976749 Replicon chromosome
Accession NZ_CP015552
Organism Staphylococcus carnosus strain TMW 2.1538

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag A7E59_RS04660 Protein ID WP_075140914.1
Coordinates 976399..976749 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag A7E59_RS04655 Protein ID WP_015900820.1
Coordinates 976235..976402 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7E59_RS04630 (A7E59_04510) 972141..972611 + 471 WP_015900825.1 PH domain-containing protein -
A7E59_RS04635 (A7E59_04515) 972604..974091 + 1488 WP_046100524.1 PH domain-containing protein -
A7E59_RS04640 (A7E59_04520) 974081..974581 + 501 WP_046100525.1 PH domain-containing protein -
A7E59_RS04645 (A7E59_04525) 974583..974936 + 354 WP_015900822.1 holo-ACP synthase -
A7E59_RS04650 (A7E59_04530) 975000..976154 + 1155 WP_046100526.1 alanine racemase -
A7E59_RS04655 (A7E59_04535) 976235..976402 + 168 WP_015900820.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
A7E59_RS04660 (A7E59_04540) 976399..976749 + 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A7E59_RS04665 (A7E59_04545) 977093..978094 + 1002 WP_015900818.1 PP2C family protein-serine/threonine phosphatase -
A7E59_RS04670 (A7E59_04550) 978170..978496 + 327 WP_046100527.1 anti-sigma factor antagonist -
A7E59_RS04675 (A7E59_04555) 978498..978977 + 480 WP_015900816.1 anti-sigma B factor RsbW -
A7E59_RS04680 (A7E59_04560) 978952..979722 + 771 WP_015900815.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T63180 WP_075140914.1 NZ_CP015552:976399-976749 [Staphylococcus carnosus]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

>T63180 NZ_CP015552:976399-976749 [Staphylococcus carnosus]
ATGATGAGGAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGGCCTGTTGT
AATTATACAAAATGACACTGGAAATAAGTATAGTCCGACAGTTATTGTGGCAGCAATTACTGGACGGATTAATAAAGCAA
AAATTCCTACTCATGTTGAAATTGAAAAAAGTAAATATAAATTGGACAAAGATTCTGTTATATTACTTGAACAGATTAGA
ACAGTCGATAAAAAGCGACTTAAAGAAAAACTGACATATTTATCAGACGAAAAGATGAAAGAAATTGATAATGCGATTCA
AATCAGCTTAGGCTTGACACATCGCAATTAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT63180 WP_015900820.1 NZ_CP015552:976235-976402 [Staphylococcus carnosus]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT63180 NZ_CP015552:976235-976402 [Staphylococcus carnosus]
ATGTCAACTTTTAATCAGAATAGAAGTTATAGTTTAGAACAGTCACTGAAAGAAGGCTATGCACAGATGGCTGACTTAAA
TCTCTCCCTCGCAACGGAGGCATTTTCAGTAGAATGTGAAGCCTGTGATTGCAATGAATCATATTTAGCTTTTGACAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References