Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 962875..963386 Replicon chromosome
Accession NZ_CP015552
Organism Staphylococcus carnosus strain TMW 2.1538

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag A7E59_RS04590 Protein ID WP_015900832.1
Coordinates 963180..963386 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag A7E59_RS04585 Protein ID WP_015900833.1
Coordinates 962875..963168 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7E59_RS04560 (A7E59_04445) 958247..958885 + 639 WP_046100516.1 thiamine phosphate synthase -
A7E59_RS04565 (A7E59_04450) 958974..959843 + 870 WP_015900837.1 membrane protein insertase YidC -
A7E59_RS04570 (A7E59_04455) 959954..960466 + 513 WP_046100517.1 GNAT family N-acetyltransferase -
A7E59_RS04575 (A7E59_04460) 960557..961204 - 648 WP_046100518.1 HD domain-containing protein -
A7E59_RS04580 (A7E59_04465) 961229..962710 - 1482 WP_046100519.1 cardiolipin synthase -
A7E59_RS04585 (A7E59_04470) 962875..963168 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
A7E59_RS04590 (A7E59_04475) 963180..963386 + 207 WP_015900832.1 heavy metal-associated domain-containing protein Toxin
A7E59_RS04595 (A7E59_04480) 963401..963610 + 210 WP_046100520.1 copper ion binding protein -
A7E59_RS04600 (A7E59_04485) 963707..965908 + 2202 WP_046100521.1 heavy metal translocating P-type ATPase -
A7E59_RS04605 965984..966124 + 141 WP_167313208.1 Lmo0850 family protein -
A7E59_RS04610 (A7E59_04490) 966196..967413 - 1218 WP_046100522.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T63179 WP_015900832.1 NZ_CP015552:963180-963386 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T63179 NZ_CP015552:963180-963386 [Staphylococcus carnosus]
ATGCAAAATAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTGCATCAACATCTTATAGAAAT
GACAGGTGTATCTGCAGTGCAAGTGGATATGGATTCAAATGAAGTCAGAATCAGTTATGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCAGGTTATCAAATATTAAATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT63179 WP_015900833.1 NZ_CP015552:962875-963168 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT63179 NZ_CP015552:962875-963168 [Staphylococcus carnosus]
ATGACCGAAAATGATAAAGCGCACCATTCAGAACAAATCAAATCCAACTTGAAAGCACGACTCAATCGAATTGAAGGACA
AGTCAGAGCAATTAACCGAATGATTGAAGAGGATGTATATTGTGATGATGTACTCACACAAATCCGTGCAACACGTTCAG
CTTTGAACAGTGTGGCAGTACGATTGCTTGATCATCACATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCGATGGAAGAATTACTTGTTACCGTTCAAAAATTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References