Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 955638..956149 Replicon chromosome
Accession NZ_CP015536
Organism Staphylococcus carnosus strain TMW 2.243

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag A2I63_RS04480 Protein ID WP_015900832.1
Coordinates 955943..956149 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag A2I63_RS04475 Protein ID WP_015900833.1
Coordinates 955638..955931 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I63_RS04450 (A2I63_04360) 951010..951648 + 639 WP_015900838.1 thiamine phosphate synthase -
A2I63_RS04455 (A2I63_04365) 951737..952606 + 870 WP_015900837.1 membrane protein insertase YidC -
A2I63_RS04460 (A2I63_04370) 952717..953229 + 513 WP_015900836.1 GNAT family N-acetyltransferase -
A2I63_RS04465 (A2I63_04375) 953320..953967 - 648 WP_015900835.1 HD domain-containing protein -
A2I63_RS04470 (A2I63_04380) 953992..955473 - 1482 WP_015900834.1 cardiolipin synthase -
A2I63_RS04475 (A2I63_04385) 955638..955931 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
A2I63_RS04480 (A2I63_04390) 955943..956149 + 207 WP_015900832.1 heavy metal-associated domain-containing protein Toxin
A2I63_RS04485 (A2I63_04395) 956164..956373 + 210 WP_015900831.1 copper ion binding protein -
A2I63_RS04490 (A2I63_04400) 956470..958671 + 2202 WP_015900830.1 heavy metal translocating P-type ATPase -
A2I63_RS04495 958747..958887 + 141 WP_167313208.1 Lmo0850 family protein -
A2I63_RS04500 (A2I63_04405) 958959..960176 - 1218 WP_015900829.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T63173 WP_015900832.1 NZ_CP015536:955943-956149 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T63173 NZ_CP015536:955943-956149 [Staphylococcus carnosus]
ATGCAAAATAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTGCATCAACATCTTATAGAAAT
GACAGGTGTATCTGCAGTGCAAGTGGATATGGATTCAAATGAAGTCAGAATCAGTTATGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCAGGTTATCAAATATTAAATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT63173 WP_015900833.1 NZ_CP015536:955638-955931 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT63173 NZ_CP015536:955638-955931 [Staphylococcus carnosus]
ATGACCGAAAATGATAAAGCGCACCATTCAGAACAAATCAAATCCAACTTGAAAGCACGACTCAATCGAATTGAAGGACA
AGTCAGAGCAATTAACCGAATGATTGAAGAGGATGTATATTGTGATGATGTACTCACACAAATCCGTGCAACACGTTCAG
CTTTGAACAGTGTGGCAGTACGATTGCTTGATCATCACATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCGATGGAAGAATTGCTTGTTACCGTTCAAAAATTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References