Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1872606..1873402 Replicon chromosome
Accession NZ_CP015532
Organism Staphylococcus carnosus strain TMW 2.212

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag A2I65_RS09240 Protein ID WP_253720121.1
Coordinates 1872938..1873402 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A2I65_RS09235 Protein ID WP_253720119.1
Coordinates 1872606..1872926 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2I65_RS09175 (A2I65_09005) 1867708..1868265 - 558 WP_253720107.1 single-stranded DNA-binding protein -
A2I65_RS09180 (A2I65_09010) 1868343..1868642 + 300 WP_253720108.1 hypothetical protein -
A2I65_RS09185 (A2I65_09015) 1868623..1868853 - 231 WP_253720109.1 hypothetical protein -
A2I65_RS09190 (A2I65_09020) 1868867..1869634 - 768 WP_253720111.1 ATP-binding protein -
A2I65_RS09195 (A2I65_09025) 1869635..1870120 - 486 WP_253720112.1 siphovirus Gp157 family protein -
A2I65_RS09200 (A2I65_09030) 1870120..1870329 - 210 WP_047130978.1 hypothetical protein -
A2I65_RS09205 (A2I65_09035) 1870393..1870575 - 183 WP_253720114.1 hypothetical protein -
A2I65_RS09210 (A2I65_09040) 1870572..1870802 - 231 WP_253720115.1 DUF771 domain-containing protein -
A2I65_RS09215 (A2I65_09045) 1870874..1871185 + 312 WP_096810293.1 hypothetical protein -
A2I65_RS09220 (A2I65_09050) 1871174..1871425 - 252 WP_096810295.1 DUF2829 domain-containing protein -
A2I65_RS09225 (A2I65_09055) 1871441..1872202 - 762 WP_253720116.1 phage antirepressor -
A2I65_RS09230 (A2I65_09060) 1872216..1872452 - 237 WP_253720118.1 helix-turn-helix transcriptional regulator -
A2I65_RS09235 (A2I65_09065) 1872606..1872926 + 321 WP_253720119.1 helix-turn-helix transcriptional regulator Antitoxin
A2I65_RS09240 (A2I65_09070) 1872938..1873402 + 465 WP_253720121.1 ImmA/IrrE family metallo-endopeptidase Toxin
A2I65_RS09245 (A2I65_09075) 1873418..1873924 + 507 WP_253720122.1 Ltp family lipoprotein -
A2I65_RS09250 1874028..1874174 + 147 WP_156483155.1 hypothetical protein -
A2I65_RS09255 (A2I65_09080) 1874171..1874818 - 648 WP_253720124.1 hypothetical protein -
A2I65_RS09260 (A2I65_09085) 1874982..1875698 + 717 WP_253720125.1 type II toxin-antitoxin system PemK/MazF family toxin -
A2I65_RS09265 (A2I65_09090) 1875896..1876924 + 1029 WP_253720127.1 tyrosine-type recombinase/integrase -
A2I65_RS09270 (A2I65_09095) 1877240..1878184 - 945 WP_253720129.1 HIRAN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1829807..1884129 54322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18327.87 Da        Isoelectric Point: 7.1825

>T63162 WP_253720121.1 NZ_CP015532:1872938-1873402 [Staphylococcus carnosus]
MGLYEKMLIEHDYIEVRETNVMPNNLHGLWLGDLILIKRNLSEVRKAEVLYEELAHHKLTYGNILDQSSFNNRKFENYAR
RYGYENALSLNKIIDAYKYGVSSLHEFAEYVQLSEEYVHTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYINKN

Download         Length: 465 bp

>T63162 NZ_CP015532:1872938-1873402 [Staphylococcus carnosus]
ATGGGATTATATGAAAAAATGTTAATAGAACATGATTATATAGAAGTCAGAGAGACAAATGTTATGCCTAATAACCTACA
CGGTCTATGGTTAGGTGATTTAATTTTAATTAAGCGAAACTTATCAGAAGTACGAAAAGCCGAAGTATTATACGAAGAAC
TAGCACACCATAAACTTACATATGGAAATATTTTAGATCAATCAAGCTTCAATAACCGAAAATTCGAAAATTACGCAAGA
AGATATGGTTATGAAAATGCTCTGTCTTTAAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTACATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAATACGTACATACAGTGTTACAACATTACAAAAACAAATTCGGTTTATCAACCT
GCCATAATGGTTATCTCATTCGATTTGAACCGTTGCAGGTTTTTAAATATATAAATAAAAATTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12312.96 Da        Isoelectric Point: 8.8595

>AT63162 WP_253720119.1 NZ_CP015532:1872606-1872926 [Staphylococcus carnosus]
MCFSKRMKQSREKQGMTLAELGKKIGKTEATVQRYESGNIKNLKNDTIENIAKALNVNPAYLMGWIDNNEQQEKPNHLAA
HLDGDLTDEEWQRVLDYVDYIRSKRK

Download         Length: 321 bp

>AT63162 NZ_CP015532:1872606-1872926 [Staphylococcus carnosus]
ATGTGCTTTTCAAAAAGAATGAAACAATCTAGAGAAAAACAAGGAATGACTTTAGCAGAACTAGGTAAAAAAATAGGCAA
AACAGAAGCTACTGTTCAACGTTACGAAAGTGGAAATATAAAAAACCTTAAAAATGACACTATCGAAAATATCGCTAAAG
CGCTAAATGTTAATCCTGCTTATTTAATGGGATGGATTGATAATAACGAACAACAAGAAAAACCTAATCATTTAGCAGCA
CATCTTGATGGTGATTTAACAGATGAAGAATGGCAACGCGTTCTAGATTATGTAGATTATATAAGAAGCAAACGCAAATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References