Detailed information of TA system TA063156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 15739..16264
• Replicon: plasmid pSJTUF10984
• Accession: NZ_CP015527
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF10984

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: A7J13_RS23990
• Protein ID: WP_001159863.1
• Coordinates: 15959..16264 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: A7J13_RS23985
• Protein ID: WP_000813641.1
• Coordinates: 15739..15957 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7J13_RS23955	11353..11739	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
A7J13_RS23960	11792..11953	+	162	WP_015059604.1	hypothetical protein	-
A7J13_RS23965	12280..13269	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
A7J13_RS23970	13763..14058	-	296	Protein_18	cytoplasmic protein	-
A7J13_RS24535	14070..14498	+	429	Protein_19	hypothetical protein	-
A7J13_RS23980	14542..15063	-	522	WP_077681952.1	hypothetical protein	-
A7J13_RS23985	15739..15957	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
A7J13_RS23990	15959..16264	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
A7J13_RS23995	16266..16556	+	291	WP_001266176.1	hypothetical protein	-
A7J13_RS24000	16553..17074	+	522	WP_000198608.1	hypothetical protein	-
A7J13_RS24005	17109..17891	+	783	WP_100926847.1	site-specific integrase	-
A7J13_RS24010	17900..18613	+	714	WP_000545756.1	EAL domain-containing protein	-
A7J13_RS24015	18617..19126	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
A7J13_RS24020	19120..19605	+	486	WP_000905606.1	membrane protein	-
A7J13_RS24025	19882..20169	-	288	WP_071530243.1	hypothetical protein	-
A7J13_RS24030	20325..20885	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59371	59371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T63156 WP_001159863.1 NZ_CP015527:15959-16264 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T63156 NZ_CP015527:15959-16264 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT63156 WP_000813641.1 NZ_CP015527:15739-15957 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT63156 NZ_CP015527:15739-15957 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6