Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 141451..142136 Replicon plasmid unnamed2
Accession NZ_CP015523
Organism Sphingomonas sp. NIC1

Toxin (Protein)


Gene name tad Uniprot ID A0A511Q3U2
Locus tag A7E77_RS17005 Protein ID WP_063690323.1
Coordinates 141451..141804 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A2T7V246
Locus tag A7E77_RS17010 Protein ID WP_063690326.1
Coordinates 141816..142136 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7E77_RS17000 138588..141309 - 2722 Protein_153 PD-(D/E)XK nuclease family protein -
A7E77_RS17005 141451..141804 + 354 WP_063690323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7E77_RS17010 141816..142136 + 321 WP_063690326.1 helix-turn-helix domain-containing protein Antitoxin
A7E77_RS17015 142210..143403 + 1194 WP_078462367.1 hypothetical protein -
A7E77_RS17020 143531..145240 + 1710 WP_063690328.1 phospholipase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177851 177851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-91)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13405.27 Da        Isoelectric Point: 7.3563

>T63154 WP_063690323.1 NZ_CP015523:141451-141804 [Sphingomonas sp. NIC1]
MRELEWMGSSRDDLVDMPEDVRSEFGHGLYLAQLGMRHVNAKPYGSSIELIERDDGDTYRCIYNVKIDDDIYVLHAFQKK
STSGIAVPKHQKETIEARLKAAQRLAAEKRALRKQAL

Download         Length: 354 bp

>T63154 NZ_CP015523:141451-141804 [Sphingomonas sp. NIC1]
ATGCGCGAACTGGAGTGGATGGGTAGTAGCAGGGACGACCTGGTCGACATGCCCGAGGATGTCCGAAGCGAGTTTGGACA
CGGCCTCTACCTAGCCCAGCTTGGAATGAGACACGTCAACGCCAAGCCGTACGGCTCGAGTATCGAGCTAATTGAGCGGG
ACGACGGCGACACCTATCGCTGCATCTACAACGTCAAGATCGACGACGATATCTACGTTCTCCACGCCTTCCAGAAAAAG
TCGACGAGCGGCATCGCCGTTCCGAAGCACCAGAAGGAAACGATCGAAGCTCGACTGAAAGCGGCTCAAAGATTGGCTGC
CGAGAAGAGAGCGCTACGCAAACAAGCCTTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11396.13 Da        Isoelectric Point: 9.9205

>AT63154 WP_063690326.1 NZ_CP015523:141816-142136 [Sphingomonas sp. NIC1]
MAVEHVTSSGNVFADLGLSDPEGRLVKSKLAAALQRSMGELGLTQTAASARMGMPQPKLSKILRGRFDGISEAYITDGLR
KLGHDVEIWVRPRHEGIGAVRVLETA

Download         Length: 321 bp

>AT63154 NZ_CP015523:141816-142136 [Sphingomonas sp. NIC1]
ATGGCAGTCGAGCATGTGACCTCCAGTGGCAACGTCTTCGCGGATCTCGGCCTTTCGGATCCGGAAGGTCGTTTGGTGAA
GTCCAAGCTCGCCGCCGCTCTTCAGCGAAGCATGGGCGAACTGGGGCTGACGCAGACCGCTGCCTCTGCTCGCATGGGCA
TGCCACAGCCCAAGCTTTCCAAGATCCTCCGCGGCCGTTTCGACGGCATCAGCGAAGCTTACATCACCGACGGGCTCCGG
AAACTCGGCCACGATGTCGAGATTTGGGTCCGGCCGCGACATGAGGGGATCGGCGCGGTGCGGGTGCTGGAAACAGCCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A511Q3U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2T7V246

References