Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 254952..256528 Replicon plasmid unnamed
Accession NZ_CP015514
Organism Vibrio vulnificus strain FORC_036

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC36_RS25615 Protein ID WP_085762241.1
Coordinates 254952..256277 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC36_RS25620 Protein ID WP_045592353.1
Coordinates 256271..256528 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC36_RS25570 (FORC36_4900) 250262..250570 - 309 WP_223371017.1 hypothetical protein -
FORC36_RS25575 (FORC36_4901) 250579..250803 - 225 WP_021485441.1 hypothetical protein -
FORC36_RS25580 (FORC36_4902) 251002..251598 + 597 WP_021485939.1 hypothetical protein -
FORC36_RS25585 (FORC36_4903) 251698..251982 + 285 WP_045592340.1 hypothetical protein -
FORC36_RS25590 (FORC36_4904) 252036..252698 + 663 WP_085762237.1 DUF262 domain-containing protein -
FORC36_RS25595 (FORC36_4905) 252797..253201 + 405 WP_085762238.1 hypothetical protein -
FORC36_RS25600 (FORC36_4906) 253235..253498 + 264 WP_045592346.1 hypothetical protein -
FORC36_RS25605 (FORC36_4907) 253673..254116 + 444 WP_085762239.1 EF-hand domain-containing protein -
FORC36_RS25610 (FORC36_4908) 254230..254916 + 687 WP_223371018.1 hypothetical protein -
FORC36_RS25615 (FORC36_4909) 254952..256277 - 1326 WP_085762241.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC36_RS25620 (FORC36_4910) 256271..256528 - 258 WP_045592353.1 helix-turn-helix domain-containing protein Antitoxin
FORC36_RS25625 (FORC36_4911) 256765..257610 - 846 WP_085762242.1 hypothetical protein -
FORC36_RS25630 (FORC36_4912) 257745..258617 + 873 WP_085762243.1 ATPase, T2SS/T4P/T4SS family -
FORC36_RS25635 (FORC36_4913) 258607..259059 + 453 WP_053319301.1 hypothetical protein -
FORC36_RS25640 (FORC36_4914) 259083..259487 - 405 WP_085762244.1 hypothetical protein -
FORC36_RS25645 (FORC36_4915) 259543..260550 - 1008 WP_085762245.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..925374 925374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49454.74 Da        Isoelectric Point: 6.7016

>T63152 WP_085762241.1 NZ_CP015514:c256277-254952 [Vibrio vulnificus]
MVKQLRVLMNGESVGVFTKEPSGAHSFQYGEEWLNSSKSRPISLSIPLRREPYRGDIVINFFDNLLPDNPQVRDRIVARY
GAKTKQPFDLLEKIGRDSVGAITLIPEGEPIPEFKGIRATELSLIKLEQVLNSYADNIPLGMVDGNDDFRISIAGAQEKT
ALLKLDERWFIPQGATPTTHIIKLPIGEIRTQDSVLDLTTSVDNELVCMRLSEAFGLPTASCDVIRAGGVRALAVERFDR
RFSQLKDWIVRLPQEDFCQVSGMPSASKYESDGGIGIEGIMDHLLGSEVPQEDRRTFMRSQVLFYLLAAIDGHSKNFSLF
IEPHGKYRLTPLYDIMSAYPLMGGRGLHERKIKLAMGLKASSGYKRKWHQIQPRHFIGTARLVKYSSDSMRDILDEFIAD
CGQVIDLVGNNLPDDINENVRDKIFEGLTKSVKKLSLGLND

Download         Length: 1326 bp

>T63152 NZ_CP015514:c256277-254952 [Vibrio vulnificus]
ATGGTAAAGCAATTACGCGTGTTAATGAATGGTGAGTCGGTAGGGGTGTTCACTAAAGAACCTAGTGGTGCTCATAGCTT
TCAATATGGCGAAGAATGGTTAAACTCTAGTAAATCTCGCCCGATATCATTATCAATCCCCCTTCGCCGTGAGCCGTACA
GGGGTGATATAGTGATTAACTTTTTCGACAACCTGCTTCCAGATAACCCTCAGGTTCGAGACCGAATCGTTGCTCGATAC
GGTGCCAAAACAAAACAGCCATTCGATCTTTTGGAAAAGATAGGGCGCGATAGTGTTGGGGCAATCACCCTTATTCCTGA
AGGCGAACCGATTCCAGAATTTAAGGGGATAAGAGCTACTGAGCTTTCCCTTATAAAGCTTGAACAAGTTCTTAATTCCT
ATGCAGACAATATCCCTTTAGGCATGGTTGATGGAAATGATGATTTCAGGATCTCCATTGCTGGCGCTCAAGAGAAAACT
GCCTTGTTGAAGTTGGATGAGCGTTGGTTTATACCGCAAGGTGCAACTCCAACCACACACATTATAAAACTTCCGATTGG
TGAAATACGGACGCAGGACAGCGTTTTAGACCTAACAACCAGTGTTGATAATGAACTCGTGTGTATGAGGCTTTCTGAAG
CGTTTGGACTGCCTACAGCCTCTTGTGACGTTATTAGGGCTGGTGGAGTAAGGGCGCTTGCCGTTGAGCGTTTCGATAGA
CGATTCTCACAACTAAAAGATTGGATTGTACGCTTGCCTCAAGAAGACTTTTGCCAGGTGTCTGGTATGCCATCAGCAAG
CAAATATGAATCAGATGGTGGTATCGGTATTGAAGGAATAATGGATCATCTTCTTGGCTCAGAGGTTCCTCAGGAAGACA
GGAGAACCTTTATGCGTTCTCAAGTTCTCTTCTATTTACTTGCTGCAATAGATGGTCACTCAAAAAACTTTTCGCTATTC
ATAGAGCCTCATGGTAAGTACCGATTAACGCCTTTGTACGACATTATGTCAGCCTACCCTCTTATGGGTGGTAGAGGGCT
TCATGAAAGAAAAATCAAGCTGGCAATGGGACTAAAGGCAAGTAGCGGATACAAACGTAAGTGGCATCAGATACAGCCTA
GACATTTTATCGGTACAGCGAGGCTGGTGAAGTATTCATCGGACTCTATGAGAGATATTCTGGATGAGTTTATTGCTGAT
TGTGGACAGGTTATCGATCTAGTTGGGAACAATCTTCCAGATGATATCAATGAGAATGTTCGGGATAAAATCTTTGAGGG
ATTAACAAAATCAGTGAAAAAACTGAGTCTTGGTCTGAATGATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9676.04 Da        Isoelectric Point: 8.7273

>AT63152 WP_045592353.1 NZ_CP015514:c256528-256271 [Vibrio vulnificus]
MLITSSRQLAIHLRDERKSRKLSQAKVADPVGIKQDTVSKFEVNPETTSIQTLFRILSSLNLEMHIVPKGQSIDPKTDNE
SDEKW

Download         Length: 258 bp

>AT63152 NZ_CP015514:c256528-256271 [Vibrio vulnificus]
ATGTTGATAACATCATCCAGGCAGTTAGCAATACATCTTCGTGATGAAAGAAAAAGCAGGAAGCTATCTCAAGCAAAAGT
TGCCGATCCAGTAGGGATAAAACAAGACACGGTTTCTAAGTTTGAGGTTAATCCTGAAACCACCAGCATTCAAACGCTAT
TTCGAATCTTATCATCGTTAAATTTGGAAATGCATATTGTGCCGAAAGGTCAAAGCATCGACCCAAAAACTGATAATGAG
AGTGATGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References