63151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 776022..777369 Replicon chromosome
Accession NZ_CP015513
Organism Vibrio vulnificus strain FORC_036

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag FORC36_RS19005 Protein ID WP_045589126.1
Coordinates 776428..777369 (+) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A854GL31
Locus tag FORC36_RS19000 Protein ID WP_017422919.1
Coordinates 776022..776426 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC36_RS18980 (FORC36_3565) 771217..771675 + 459 WP_011081157.1 hypothetical protein -
FORC36_RS18985 (FORC36_3566) 771865..772611 + 747 WP_085761681.1 carbon-nitrogen hydrolase family protein -
FORC36_RS18990 (FORC36_3568) 773111..773875 + 765 WP_085761682.1 nucleotidyltransferase domain-containing protein -
FORC36_RS18995 (FORC36_3569) 773928..775688 - 1761 WP_085761683.1 ABC transporter ATP-binding protein/permease -
FORC36_RS19000 (FORC36_3570) 776022..776426 + 405 WP_017422919.1 DUF6088 family protein Antitoxin
FORC36_RS19005 (FORC36_3571) 776428..777369 + 942 WP_045589126.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FORC36_RS19010 (FORC36_3572) 777934..778290 + 357 WP_223370936.1 hypothetical protein -
FORC36_RS19015 (FORC36_3573) 778366..779310 + 945 WP_223370937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 36069.51 Da        Isoelectric Point: 5.3076

>T63151 WP_045589126.1 NZ_CP015513:776428-777369 [Vibrio vulnificus]
MNALKQQFLEVSDALELGNPAIIEKDFWVVALLAELAKVSPEYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKGVRKAWVNEIEQAIIHSERFTVETRSVRDEYRYVEFELRYPQQFSQVPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSSFDCVSVYATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLTMSELNSIDGLFKAVL
EEDIARFGNQHAEFVANPKQELQLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T63151 NZ_CP015513:776428-777369 [Vibrio vulnificus]
ATGAACGCACTAAAACAACAATTTCTTGAGGTTTCCGACGCGCTTGAGCTCGGAAATCCTGCCATCATTGAAAAAGATTT
CTGGGTCGTCGCCTTACTTGCCGAGCTAGCAAAAGTTTCTCCTGAATATCATCAAATGGTCTTTTCCGGCGGCACGGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCAAGCGTTTGATGAA
CTGAGTCGAGCAAAAAAGAAAGGCGTTAGAAAGGCATGGGTTAACGAGATTGAACAGGCGATCATTCATTCAGAACGATT
TACCGTTGAAACGCGATCTGTGCGAGATGAGTACCGTTACGTTGAGTTTGAACTCAGATATCCGCAACAGTTTAGTCAAG
TTCCCTGTCTTCGTCCCATCATTAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCACTGGTTGCAGAGTTGTACCAACAACCGCACGAAGTGAGTTCATTTGATTGCGTCTCTGTCTATGCCACATTGGTTGA
AAAAATCATTTCGATGCTGCGCCGTACAATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTCTAGTTCGCC
ATATCTACGATGTGCATTGCATAACAAAGCTCACAATGTCTGAACTCAACTCGATTGACGGCCTTTTCAAAGCGGTATTG
GAAGAAGATATTGCCCGCTTTGGCAATCAACATGCAGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAAAATCCCATTTTCCGCCAACGTTTTCAGGACTTTGTCACACCAATGGTGTTTAACACTGAGCCCCATG
ATTTTGATACCTGCTTTGCCTCATTCAAGCGAATTGCAGCGTCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15115.43 Da        Isoelectric Point: 10.6258

>AT63151 WP_017422919.1 NZ_CP015513:776022-776426 [Vibrio vulnificus]
MTAVDRICQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALVRE
ILKMKGVDFEMDSLSQQSLSGASTQIPSSVHYSWNPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT63151 NZ_CP015513:776022-776426 [Vibrio vulnificus]
ATGACAGCAGTAGACCGCATTTGTCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGACGGATT
TGCAAGTTACGACCAAATAGGTCGGGCATTGAGGCAGCTTGTACAGCAAGGGGAGCTAATGAAGCTTGGCTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGTAAGCCTATGCCTACCAATCCAGGTGGTACCGATGCTCTTGTGCGTGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAAATGGATAGTCTATCGCAACAAAGTCTTTCAGGTGCGAGTACCCAAATTCC
ATCCTCTGTTCACTATTCATGGAACCCAAAACAGTTTAATCGCAAACTGGTGGTTGGTAGCCGTGTGCTGAACTTGCCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A854GL31

References