Detailed information of TA system TA063149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2190307..2191868
• Replicon: chromosome
• Accession: NZ_CP015512
• Organism: Vibrio vulnificus strain FORC_036

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1W6M5G8
• Locus tag: FORC36_RS10625
• Protein ID: WP_069504143.1
• Coordinates: 2190307..2191635 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FORC36_RS10630
• Protein ID: WP_025787161.1
• Coordinates: 2191629..2191868 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC36_RS10605 (FORC36_1971)	2185495..2185959	-	465	WP_011079944.1	DUF2846 domain-containing protein	-
FORC36_RS10610 (FORC36_1972)	2186160..2187212	-	1053	WP_013571360.1	GGDEF domain-containing protein	-
FORC36_RS10615 (FORC36_1973)	2187350..2187985	-	636	WP_013571359.1	magnesium transporter	-
FORC36_RS10620 (FORC36_1974)	2188793..2190115	+	1323	WP_085761233.1	site-specific integrase	-
FORC36_RS10625 (FORC36_1975)	2190307..2191635	-	1329	WP_069504143.1	type II toxin-antitoxin system HipA family toxin	Toxin
FORC36_RS10630 (FORC36_1976)	2191629..2191868	-	240	WP_025787161.1	helix-turn-helix domain-containing protein	Antitoxin
FORC36_RS10635 (FORC36_1977)	2192450..2193142	-	693	WP_062866031.1	SDR family oxidoreductase	-
FORC36_RS10640 (FORC36_1978)	2193226..2194422	-	1197	WP_062866030.1	MFS transporter	-
FORC36_RS10645 (FORC36_1979)	2194611..2195492	+	882	WP_062866029.1	LysR family transcriptional regulator	-
FORC36_RS10650 (FORC36_1980)	2195626..2196723	+	1098	WP_085761234.1	alkene reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2188558..2224805	36247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49723.13 Da
• Isoelectric Point: 8.5824

>T63149 WP_069504143.1 NZ_CP015512:c2191635-2190307 [Vibrio vulnificus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSGWVLAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KAETKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
SMAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T63149 NZ_CP015512:c2191635-2190307 [Vibrio vulnificus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGGTTGGGTTTTAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAACAGATACGAGATAGAATAGCTGCCCGCTAT
AAAGCAGAGACTAAACAGCCATTCGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGCTTTGATGTAGATGATCATCGAACCATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGACGCTCCTTTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTGTTTCACGATGGAAGATGGATGCTACCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCTAGTGTCGATAATGAGTTGATTTGTATGAGGCTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCTGTTGAGCGATTTGACCGA
AAATTATCTTCTGATAACAGCTATTACTTGCGCTTGCCCCATGAGGATTTTTGCCAGGCAAAAGGGATTCCCTCAGCTAG
AAAATATGAAATTGACGGTGGTATCGGCATAGAAGAATCTATTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATCTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGGCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGATGAGTTTGAA
TCGATGGCAATGGAGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAAATTCAATTGACAAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.02 Da
• Isoelectric Point: 7.2039

>AT63149 WP_025787161.1 NZ_CP015512:c2191868-2191629 [Vibrio vulnificus]
MLVNTPTALGNALREARKESGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHIIETKGAVDEW

Nucleotide

• Length: 240 bp

>AT63149 NZ_CP015512:c2191868-2191629 [Vibrio vulnificus]
ATGCTAGTCAACACACCGACAGCTCTCGGCAATGCGTTACGCGAAGCCCGAAAGGAAAGCGGCCTAAAGCAAACAGATCT
TGGTCTGCGACAAGCAACAGTATCTAATTTTGAAAGCAATCCTGAAAAATCCACGATAGAAACATTGTTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCGAAAGGCAAGCACATTATTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Structures

Toxin

• AlphaFold DB: A0A1W6M5G8