Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1699163..1699701 Replicon chromosome
Accession NZ_CP015512
Organism Vibrio vulnificus strain FORC_036

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC36_RS08090 Protein ID WP_001247271.1
Coordinates 1699402..1699701 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC36_RS08085 Protein ID WP_011080384.1
Coordinates 1699163..1699405 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC36_RS08025 1694678..1694779 - 102 WP_103193372.1 DUF3265 domain-containing protein -
FORC36_RS08030 (FORC36_1520) 1694810..1695097 - 288 WP_085761065.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC36_RS08035 (FORC36_1521) 1695094..1695375 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC36_RS29710 1695466..1695558 - 93 Protein_1521 DUF3265 domain-containing protein -
FORC36_RS08045 (FORC36_1522) 1695584..1696051 - 468 WP_043921028.1 cold shock domain-containing protein -
FORC36_RS08050 (FORC36_1523) 1696173..1696733 - 561 WP_085761066.1 hypothetical protein -
FORC36_RS08060 (FORC36_1524) 1696883..1697224 - 342 WP_013571682.1 hypothetical protein -
FORC36_RS29715 1697279..1697341 - 63 WP_223370875.1 DUF3265 domain-containing protein -
FORC36_RS08070 1697715..1697843 - 129 WP_085761452.1 DUF3265 domain-containing protein -
FORC36_RS08075 (FORC36_1525) 1697840..1698199 - 360 WP_085761067.1 VOC family protein -
FORC36_RS08080 (FORC36_1526) 1698362..1698958 - 597 WP_085761068.1 DJ-1/PfpI family protein -
FORC36_RS08085 (FORC36_1527) 1699163..1699405 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC36_RS08090 (FORC36_1528) 1699402..1699701 + 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC36_RS08095 1699709..1699819 - 111 WP_082798391.1 DUF3265 domain-containing protein -
FORC36_RS08100 (FORC36_1529) 1699827..1700111 - 285 WP_021452995.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
FORC36_RS29720 1700201..1700266 - 66 Protein_1533 DUF3265 domain-containing protein -
FORC36_RS29725 (FORC36_1531) 1700465..1700626 + 162 WP_165386688.1 hypothetical protein -
FORC36_RS08120 (FORC36_1532) 1700844..1701152 - 309 WP_085761070.1 hypothetical protein -
FORC36_RS08125 1701201..1701311 - 111 WP_085761453.1 DUF3265 domain-containing protein -
FORC36_RS08130 (FORC36_1533) 1701389..1701730 - 342 WP_123772850.1 hypothetical protein -
FORC36_RS08135 1701694..1701783 - 90 WP_207218436.1 DUF3265 domain-containing protein -
FORC36_RS08140 (FORC36_1534) 1701801..1702124 - 324 WP_085761072.1 hypothetical protein -
FORC36_RS30135 1702099..1702212 - 114 Protein_1540 DUF3265 domain-containing protein -
FORC36_RS29730 1702167..1702304 - 138 WP_223156389.1 DUF3265 domain-containing protein -
FORC36_RS08150 (FORC36_1535) 1702285..1702584 - 300 WP_045619989.1 hypothetical protein -
FORC36_RS08155 (FORC36_1536) 1702641..1703492 - 852 WP_085761052.1 IS3 family transposase -
FORC36_RS08160 (FORC36_1537) 1703489..1703797 - 309 WP_004413754.1 transposase -
FORC36_RS08165 1703808..1703990 - 183 WP_085761075.1 DUF3265 domain-containing protein -
FORC36_RS08170 (FORC36_1538) 1703987..1704520 - 534 WP_223370802.1 AAA family ATPase -
FORC36_RS08175 1704560..1704652 - 93 WP_004748931.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1518377..1799258 280881
- inside Integron - - 1671690..1750366 78676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T63148 WP_001247271.1 NZ_CP015512:1699402-1699701 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T63148 NZ_CP015512:1699402-1699701 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAAATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT63148 WP_011080384.1 NZ_CP015512:1699163-1699405 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT63148 NZ_CP015512:1699163-1699405 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGTCGCTATGG
CTCTGCAAGTGAAGTCATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References