Detailed information of TA system TA063147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1694810..1695375
• Replicon: chromosome
• Accession: NZ_CP015512
• Organism: Vibrio vulnificus strain FORC_036

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC36_RS08030
• Protein ID: WP_085761065.1
• Coordinates: 1694810..1695097 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: FORC36_RS08035
• Protein ID: WP_000086647.1
• Coordinates: 1695094..1695375 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC36_RS07975	1690171..1690296	-	126	WP_085761060.1	DUF3265 domain-containing protein	-
FORC36_RS07980 (FORC36_1514)	1690333..1690740	-	408	WP_172572417.1	hypothetical protein	-
FORC36_RS07985 (FORC36_1515)	1690890..1691312	-	423	WP_013571695.1	VOC family protein	-
FORC36_RS07995	1691946..1692413	-	468	WP_085761061.1	DUF1643 domain-containing protein	-
FORC36_RS08000	1692440..1692541	-	102	WP_223370873.1	DUF3265 domain-containing protein	-
FORC36_RS08005 (FORC36_1517)	1692567..1693031	-	465	WP_085761062.1	ASCH domain-containing protein	-
FORC36_RS08010	1693024..1693182	-	159	WP_085761063.1	DUF3265 domain-containing protein	-
FORC36_RS08015 (FORC36_1518)	1693179..1693634	-	456	WP_005464666.1	GNAT family N-acetyltransferase	-
FORC36_RS08020 (FORC36_1519)	1693780..1694655	-	876	WP_085761064.1	hypothetical protein	-
FORC36_RS08025	1694678..1694779	-	102	WP_103193372.1	DUF3265 domain-containing protein	-
FORC36_RS08030 (FORC36_1520)	1694810..1695097	-	288	WP_085761065.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC36_RS08035 (FORC36_1521)	1695094..1695375	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC36_RS29710	1695466..1695558	-	93	Protein_1521	DUF3265 domain-containing protein	-
FORC36_RS08045 (FORC36_1522)	1695584..1696051	-	468	WP_043921028.1	cold shock domain-containing protein	-
FORC36_RS08050 (FORC36_1523)	1696173..1696733	-	561	WP_085761066.1	hypothetical protein	-
FORC36_RS08060 (FORC36_1524)	1696883..1697224	-	342	WP_013571682.1	hypothetical protein	-
FORC36_RS29715	1697279..1697341	-	63	WP_223370875.1	DUF3265 domain-containing protein	-
FORC36_RS08070	1697715..1697843	-	129	WP_085761452.1	DUF3265 domain-containing protein	-
FORC36_RS08075 (FORC36_1525)	1697840..1698199	-	360	WP_085761067.1	VOC family protein	-
FORC36_RS08080 (FORC36_1526)	1698362..1698958	-	597	WP_085761068.1	DJ-1/PfpI family protein	-
FORC36_RS08085 (FORC36_1527)	1699163..1699405	+	243	WP_011080384.1	type II toxin-antitoxin system ParD family antitoxin	-
FORC36_RS08090 (FORC36_1528)	1699402..1699701	+	300	WP_001247271.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FORC36_RS08095	1699709..1699819	-	111	WP_082798391.1	DUF3265 domain-containing protein	-
FORC36_RS08100 (FORC36_1529)	1699827..1700111	-	285	WP_021452995.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
FORC36_RS29720	1700201..1700266	-	66	Protein_1533	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	1518377..1799258	280881
	-	inside	Integron	-	-	1671690..1750366	78676

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11045.73 Da
• Isoelectric Point: 5.1098

>T63147 WP_085761065.1 NZ_CP015512:c1695097-1694810 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRI
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T63147 NZ_CP015512:c1695097-1694810 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAACTATCGCGAAATCATCTTTGGCCACTACCGTATTATCTACAGTTTAAGCCACGAAATTCGCATA
CTAACAGTTCGTAACTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT63147 WP_000086647.1 NZ_CP015512:c1695375-1695094 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT63147 NZ_CP015512:c1695375-1695094 [Vibrio vulnificus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0