Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1657460..1658009 | Replicon | chromosome |
| Accession | NZ_CP015512 | ||
| Organism | Vibrio vulnificus strain FORC_036 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | FORC36_RS07640 | Protein ID | WP_085761024.1 |
| Coordinates | 1657710..1658009 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | FORC36_RS07635 | Protein ID | WP_085761023.1 |
| Coordinates | 1657460..1657702 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC36_RS29665 | 1653335..1653528 | + | 194 | Protein_1442 | IS3 family transposase | - |
| FORC36_RS07605 (FORC36_1469) | 1653665..1654863 | + | 1199 | Protein_1443 | IS4 family transposase | - |
| FORC36_RS07610 | 1654858..1655013 | - | 156 | WP_085761021.1 | DUF3265 domain-containing protein | - |
| FORC36_RS07615 (FORC36_1470) | 1654998..1655414 | - | 417 | WP_223370799.1 | hypothetical protein | - |
| FORC36_RS07620 (FORC36_1471) | 1655411..1655845 | - | 435 | WP_085761022.1 | T6SS effector amidase Tae4 family protein | - |
| FORC36_RS07625 (FORC36_1472) | 1656050..1656358 | + | 309 | WP_004413754.1 | transposase | - |
| FORC36_RS29670 (FORC36_1473) | 1656355..1657206 | + | 852 | WP_085761052.1 | IS3 family transposase | - |
| FORC36_RS07635 (FORC36_1474) | 1657460..1657702 | + | 243 | WP_085761023.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC36_RS07640 (FORC36_1475) | 1657710..1658009 | + | 300 | WP_085761024.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC36_RS07645 | 1658068..1658157 | - | 90 | WP_079748782.1 | DUF3265 domain-containing protein | - |
| FORC36_RS07650 | 1658181..1658537 | - | 357 | WP_085761025.1 | hypothetical protein | - |
| FORC36_RS07655 | 1658613..1658711 | - | 99 | WP_237282426.1 | hypothetical protein | - |
| FORC36_RS07660 (FORC36_1477) | 1658698..1659000 | - | 303 | WP_118893592.1 | hypothetical protein | - |
| FORC36_RS07665 | 1658993..1659145 | - | 153 | WP_085761027.1 | DUF3265 domain-containing protein | - |
| FORC36_RS07670 (FORC36_1478) | 1659342..1660298 | + | 957 | WP_085761028.1 | IS110 family transposase | - |
| FORC36_RS30110 | 1660663..1660848 | - | 186 | WP_237282427.1 | DUF3265 domain-containing protein | - |
| FORC36_RS29680 | 1661178..1661243 | - | 66 | WP_223370869.1 | DUF3265 domain-containing protein | - |
| FORC36_RS07690 (FORC36_1479) | 1661340..1661645 | - | 306 | WP_025611486.1 | hypothetical protein | - |
| FORC36_RS07695 (FORC36_1480) | 1661778..1662140 | - | 363 | WP_011150416.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1518377..1799258 | 280881 | |
| - | flank | IS/Tn | - | - | 1659342..1660298 | 956 | |
| - | inside | Integron | - | - | 1656355..1662140 | 5785 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11515.15 Da Isoelectric Point: 9.8446
>T63146 WP_085761024.1 NZ_CP015512:1657710-1658009 [Vibrio vulnificus]
MQKNKYKLSNLAQSHLRKAKNYTVENFSELQWRNYKDTLLSRFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK
MQKNKYKLSNLAQSHLRKAKNYTVENFSELQWRNYKDTLLSRFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK
Download Length: 300 bp
>T63146 NZ_CP015512:1657710-1658009 [Vibrio vulnificus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGCAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTACAAAGACACTCTGCTATCACGGTTTCAAATGCTAGCTGATAACCCTGGGTTAGGAA
GAAGCTGTGACGAGATATACCCAAATGGCTTTTACTTCCCGATTGGAAAACACACCGCTTATTTCACTAAAGAAGATGGC
TTTATCTTAGTCGTGGCTGTCTTAGGTCAATCACAGCTCCCACAGAACCATCTGAAATAA
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGCAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTACAAAGACACTCTGCTATCACGGTTTCAAATGCTAGCTGATAACCCTGGGTTAGGAA
GAAGCTGTGACGAGATATACCCAAATGGCTTTTACTTCCCGATTGGAAAACACACCGCTTATTTCACTAAAGAAGATGGC
TTTATCTTAGTCGTGGCTGTCTTAGGTCAATCACAGCTCCCACAGAACCATCTGAAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.29 Da Isoelectric Point: 5.6926
>AT63146 WP_085761023.1 NZ_CP015512:1657460-1657702 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPIKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNAIDGESFLNSL
MHTLTANDAKRNFGELLLSAQREPIKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNAIDGESFLNSL
Download Length: 243 bp
>AT63146 NZ_CP015512:1657460-1657702 [Vibrio vulnificus]
ATGCATACATTAACAGCGAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCGATAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGTTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACGCCATTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA
ATGCATACATTAACAGCGAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCGATAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGTTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACGCCATTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|