Detailed information of TA system TA063144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3210747..3211270
• Replicon: chromosome
• Accession: NZ_CP015511
• Organism: Brevundimonas sp. GW460-12-10-14-LB2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A4249_RS16845
• Protein ID: WP_197458413.1
• Coordinates: 3210747..3211022 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: A4249_RS15915
• Protein ID: WP_197458414.1
• Coordinates: 3211019..3211270 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4249_RS15875	3206191..3206568	+	378	WP_197458411.1	hypothetical protein	-
A4249_RS15880	3206565..3207428	+	864	WP_066554424.1	hypothetical protein	-
A4249_RS15885	3207434..3207892	+	459	WP_066555372.1	tol-pal system-associated acyl-CoA thioesterase	-
A4249_RS15890	3207918..3208352	+	435	WP_066554425.1	hypothetical protein	-
A4249_RS15895	3208493..3209245	+	753	WP_066554426.1	protein TolQ	-
A4249_RS15900	3209249..3209701	+	453	WP_066554427.1	ExbD/TolR family protein	-
A4249_RS16835	3209707..3210585	+	879	WP_066554430.1	cell envelope integrity protein TolA	-
A4249_RS16840	3210589..3210750	-	162	WP_197458412.1	hypothetical protein	-
A4249_RS16845	3210747..3211022	-	276	WP_197458413.1	hypothetical protein	Toxin
A4249_RS15915	3211019..3211270	-	252	WP_197458414.1	CopG family transcriptional regulator	Antitoxin
A4249_RS15920	3211394..3212758	+	1365	WP_066554431.1	Tol-Pal system protein TolB	-
A4249_RS15925	3212899..3213462	+	564	WP_055753951.1	peptidoglycan-associated lipoprotein Pal	-
A4249_RS15930	3213590..3214732	+	1143	WP_066554433.1	DUF3667 domain-containing protein	-
A4249_RS15935	3214774..3215619	+	846	WP_066554439.1	tol-pal system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9783.23 Da
• Isoelectric Point: 6.4757

>T63144 WP_197458413.1 NZ_CP015511:c3211022-3210747 [Brevundimonas sp. GW460-12-10-14-LB2]
MIALLDVSVLIALIDPAHTEHLTAHAWFAREHQAGWATCPLTENGALRILSNPKYPNSPGAPAQVLPALHSLLSQPGHAF
WPDGISCWATV

Nucleotide

• Length: 276 bp

>T63144 NZ_CP015511:c3211022-3210747 [Brevundimonas sp. GW460-12-10-14-LB2]
TTGATCGCGCTTTTGGACGTCAGCGTCCTGATCGCATTGATCGATCCAGCCCATACCGAGCATCTCACCGCCCACGCCTG
GTTCGCACGTGAGCATCAAGCCGGTTGGGCGACCTGCCCGCTGACCGAGAACGGCGCGCTTCGAATCCTCAGCAATCCCA
AATATCCGAACTCGCCGGGTGCGCCGGCGCAGGTGTTGCCGGCGCTTCATTCCTTGCTGAGCCAACCCGGCCATGCGTTC
TGGCCCGACGGCATCAGTTGCTGGGCGACCGTTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9168.46 Da
• Isoelectric Point: 8.7591

>AT63144 WP_197458414.1 NZ_CP015511:c3211270-3211019 [Brevundimonas sp. GW460-12-10-14-LB2]
MHYLTAMRTTLAIDDDVLNAARAIAVQTRTSVGEVISDLARRSITQAKPDTSPEFRNGIRLLPHRKGAVVTTEQINALRD
ELP

Nucleotide

• Length: 252 bp

>AT63144 NZ_CP015511:c3211270-3211019 [Brevundimonas sp. GW460-12-10-14-LB2]
ATGCACTATCTTACAGCCATGCGCACTACACTCGCCATCGACGACGACGTGTTGAACGCCGCACGGGCCATCGCGGTTCA
GACCCGAACCTCTGTGGGCGAAGTCATTTCCGATCTCGCGCGCCGCTCGATCACACAGGCCAAGCCGGACACGTCGCCCG
AATTCCGCAACGGCATTCGTCTCCTGCCGCACCGCAAGGGCGCTGTGGTGACGACCGAACAGATCAACGCTCTGCGCGAT
GAACTGCCTTGA