Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3210747..3211270 Replicon chromosome
Accession NZ_CP015511
Organism Brevundimonas sp. GW460-12-10-14-LB2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A4249_RS16845 Protein ID WP_197458413.1
Coordinates 3210747..3211022 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A4249_RS15915 Protein ID WP_197458414.1
Coordinates 3211019..3211270 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4249_RS15875 3206191..3206568 + 378 WP_197458411.1 hypothetical protein -
A4249_RS15880 3206565..3207428 + 864 WP_066554424.1 hypothetical protein -
A4249_RS15885 3207434..3207892 + 459 WP_066555372.1 tol-pal system-associated acyl-CoA thioesterase -
A4249_RS15890 3207918..3208352 + 435 WP_066554425.1 hypothetical protein -
A4249_RS15895 3208493..3209245 + 753 WP_066554426.1 protein TolQ -
A4249_RS15900 3209249..3209701 + 453 WP_066554427.1 ExbD/TolR family protein -
A4249_RS16835 3209707..3210585 + 879 WP_066554430.1 cell envelope integrity protein TolA -
A4249_RS16840 3210589..3210750 - 162 WP_197458412.1 hypothetical protein -
A4249_RS16845 3210747..3211022 - 276 WP_197458413.1 hypothetical protein Toxin
A4249_RS15915 3211019..3211270 - 252 WP_197458414.1 CopG family transcriptional regulator Antitoxin
A4249_RS15920 3211394..3212758 + 1365 WP_066554431.1 Tol-Pal system protein TolB -
A4249_RS15925 3212899..3213462 + 564 WP_055753951.1 peptidoglycan-associated lipoprotein Pal -
A4249_RS15930 3213590..3214732 + 1143 WP_066554433.1 DUF3667 domain-containing protein -
A4249_RS15935 3214774..3215619 + 846 WP_066554439.1 tol-pal system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 9783.23 Da        Isoelectric Point: 6.4757

>T63144 WP_197458413.1 NZ_CP015511:c3211022-3210747 [Brevundimonas sp. GW460-12-10-14-LB2]
MIALLDVSVLIALIDPAHTEHLTAHAWFAREHQAGWATCPLTENGALRILSNPKYPNSPGAPAQVLPALHSLLSQPGHAF
WPDGISCWATV

Download         Length: 276 bp

>T63144 NZ_CP015511:c3211022-3210747 [Brevundimonas sp. GW460-12-10-14-LB2]
TTGATCGCGCTTTTGGACGTCAGCGTCCTGATCGCATTGATCGATCCAGCCCATACCGAGCATCTCACCGCCCACGCCTG
GTTCGCACGTGAGCATCAAGCCGGTTGGGCGACCTGCCCGCTGACCGAGAACGGCGCGCTTCGAATCCTCAGCAATCCCA
AATATCCGAACTCGCCGGGTGCGCCGGCGCAGGTGTTGCCGGCGCTTCATTCCTTGCTGAGCCAACCCGGCCATGCGTTC
TGGCCCGACGGCATCAGTTGCTGGGCGACCGTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9168.46 Da        Isoelectric Point: 8.7591

>AT63144 WP_197458414.1 NZ_CP015511:c3211270-3211019 [Brevundimonas sp. GW460-12-10-14-LB2]
MHYLTAMRTTLAIDDDVLNAARAIAVQTRTSVGEVISDLARRSITQAKPDTSPEFRNGIRLLPHRKGAVVTTEQINALRD
ELP

Download         Length: 252 bp

>AT63144 NZ_CP015511:c3211270-3211019 [Brevundimonas sp. GW460-12-10-14-LB2]
ATGCACTATCTTACAGCCATGCGCACTACACTCGCCATCGACGACGACGTGTTGAACGCCGCACGGGCCATCGCGGTTCA
GACCCGAACCTCTGTGGGCGAAGTCATTTCCGATCTCGCGCGCCGCTCGATCACACAGGCCAAGCCGGACACGTCGCCCG
AATTCCGCAACGGCATTCGTCTCCTGCCGCACCGCAAGGGCGCTGTGGTGACGACCGAACAGATCAACGCTCTGCGCGAT
GAACTGCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References