Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-RelB
Location 60753..61267 Replicon chromosome
Accession NZ_CP015511
Organism Brevundimonas sp. GW460-12-10-14-LB2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A168MXB3
Locus tag A4249_RS00355 Protein ID WP_066549813.1
Coordinates 60753..61013 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A160I1W3
Locus tag A4249_RS00360 Protein ID WP_066554535.1
Coordinates 61010..61267 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4249_RS00330 55818..56057 - 240 WP_066549799.1 type II toxin-antitoxin system ParD family antitoxin -
A4249_RS00335 56112..57683 - 1572 WP_066549803.1 response regulator -
A4249_RS16420 57796..58182 + 387 WP_156494554.1 hypothetical protein -
A4249_RS00340 58095..58532 + 438 WP_066549806.1 hypothetical protein -
A4249_RS00345 58529..59890 - 1362 WP_066549809.1 glutamate--cysteine ligase -
A4249_RS00350 60025..60756 - 732 WP_066549811.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
A4249_RS00355 60753..61013 - 261 WP_066549813.1 Txe/YoeB family addiction module toxin Toxin
A4249_RS00360 61010..61267 - 258 WP_066554535.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A4249_RS00365 61311..61526 - 216 WP_156494556.1 hypothetical protein -
A4249_RS00370 61573..62736 - 1164 WP_066549821.1 acyl-CoA dehydrogenase family protein -
A4249_RS00375 62833..64617 - 1785 WP_066549823.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
A4249_RS00380 64621..65103 - 483 WP_039244783.1 MerR family DNA-binding transcriptional regulator -
A4249_RS00385 65293..65709 - 417 WP_055806164.1 DoxX family protein -
A4249_RS00390 65920..66138 - 219 WP_039244779.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10600.05 Da        Isoelectric Point: 9.4792

>T63143 WP_066549813.1 NZ_CP015511:c61013-60753 [Brevundimonas sp. GW460-12-10-14-LB2]
MKLTFQTYGWEDYLHWQDHDRKMVRKLNRLIRECQRTPFSGTGKPEPLKGDFAGWWSRRIDQEHRLVYRVTDDALLIAQC
RYHYDR

Download         Length: 261 bp

>T63143 NZ_CP015511:c61013-60753 [Brevundimonas sp. GW460-12-10-14-LB2]
ATGAAGCTGACCTTCCAGACCTACGGGTGGGAGGATTATCTTCACTGGCAAGACCATGATCGCAAGATGGTGCGAAAGCT
CAATCGGCTGATCAGGGAATGCCAGCGGACGCCTTTTTCCGGGACTGGAAAGCCAGAACCGTTGAAGGGCGATTTTGCGG
GATGGTGGTCGCGGCGCATCGACCAGGAACATCGTCTCGTCTATCGCGTGACCGACGATGCGCTTTTGATCGCCCAATGC
CGCTATCACTACGACCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9334.52 Da        Isoelectric Point: 4.4488

>AT63143 WP_066554535.1 NZ_CP015511:c61267-61010 [Brevundimonas sp. GW460-12-10-14-LB2]
MNAMSVTELRKNLASVIDRVTADHDYTIITREGGKPAAVLMSLEDFASWQETEYLLRSPANAARLREAISELDAGGGQVR
ALIEE

Download         Length: 258 bp

>AT63143 NZ_CP015511:c61267-61010 [Brevundimonas sp. GW460-12-10-14-LB2]
ATGAACGCGATGTCCGTCACCGAACTCCGCAAGAACCTCGCCTCGGTCATCGACCGGGTGACGGCGGATCATGACTACAC
CATCATCACACGCGAGGGCGGCAAACCCGCAGCGGTGCTGATGTCGTTGGAAGACTTCGCCTCTTGGCAAGAGACCGAGT
ACCTGCTGCGCAGCCCGGCGAACGCCGCGCGATTGCGTGAGGCGATCTCCGAACTCGATGCGGGCGGCGGTCAGGTTCGC
GCACTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168MXB3

Antitoxin

Source ID Structure
AlphaFold DB A0A160I1W3

References