Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 269969..270605 Replicon chromosome
Accession NZ_CP015506
Organism Bacillus oceanisediminis 2691

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag A361_RS01445 Protein ID WP_009336311.1
Coordinates 270255..270605 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160MHA2
Locus tag A361_RS01440 Protein ID WP_026041666.1
Coordinates 269969..270250 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A361_RS01420 265866..266591 - 726 WP_019381246.1 rhomboid family intramembrane serine protease -
A361_RS01425 266756..267109 + 354 WP_019381247.1 holo-ACP synthase -
A361_RS01430 267254..268267 + 1014 WP_019381248.1 outer membrane lipoprotein carrier protein LolA -
A361_RS01435 268321..269592 + 1272 WP_019381249.1 alanine racemase -
A361_RS01440 269969..270250 + 282 WP_026041666.1 CopG family ribbon-helix-helix protein Antitoxin
A361_RS01445 270255..270605 + 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
A361_RS01450 270987..271820 + 834 WP_009336310.1 STAS domain-containing protein -
A361_RS01455 271817..272179 + 363 WP_009336309.1 STAS domain-containing protein -
A361_RS01460 272184..272585 + 402 WP_009336308.1 anti-sigma regulatory factor -
A361_RS01465 272597..273607 + 1011 WP_019381250.1 PP2C family protein-serine/threonine phosphatase -
A361_RS01470 273668..274000 + 333 WP_009336305.1 anti-sigma factor antagonist -
A361_RS01475 273997..274470 + 474 WP_009336304.1 anti-sigma B factor RsbW -
A361_RS01480 274448..275242 + 795 WP_009336303.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T63140 WP_009336311.1 NZ_CP015506:270255-270605 [Bacillus oceanisediminis 2691]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

>T63140 NZ_CP015506:270255-270605 [Bacillus oceanisediminis 2691]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10817.30 Da        Isoelectric Point: 7.2025

>AT63140 WP_026041666.1 NZ_CP015506:269969-270250 [Bacillus oceanisediminis 2691]
VSDSSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT63140 NZ_CP015506:269969-270250 [Bacillus oceanisediminis 2691]
GTGTCTGATTCCAGCACAACAACAGAGATAATGGTAAAGTTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB A0A160MHA2

References