Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazF-pemI/MazF(toxin) |
Location | 269969..270605 | Replicon | chromosome |
Accession | NZ_CP015506 | ||
Organism | Bacillus oceanisediminis 2691 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | W7KPR3 |
Locus tag | A361_RS01445 | Protein ID | WP_009336311.1 |
Coordinates | 270255..270605 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A160MHA2 |
Locus tag | A361_RS01440 | Protein ID | WP_026041666.1 |
Coordinates | 269969..270250 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A361_RS01420 | 265866..266591 | - | 726 | WP_019381246.1 | rhomboid family intramembrane serine protease | - |
A361_RS01425 | 266756..267109 | + | 354 | WP_019381247.1 | holo-ACP synthase | - |
A361_RS01430 | 267254..268267 | + | 1014 | WP_019381248.1 | outer membrane lipoprotein carrier protein LolA | - |
A361_RS01435 | 268321..269592 | + | 1272 | WP_019381249.1 | alanine racemase | - |
A361_RS01440 | 269969..270250 | + | 282 | WP_026041666.1 | CopG family ribbon-helix-helix protein | Antitoxin |
A361_RS01445 | 270255..270605 | + | 351 | WP_009336311.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
A361_RS01450 | 270987..271820 | + | 834 | WP_009336310.1 | STAS domain-containing protein | - |
A361_RS01455 | 271817..272179 | + | 363 | WP_009336309.1 | STAS domain-containing protein | - |
A361_RS01460 | 272184..272585 | + | 402 | WP_009336308.1 | anti-sigma regulatory factor | - |
A361_RS01465 | 272597..273607 | + | 1011 | WP_019381250.1 | PP2C family protein-serine/threonine phosphatase | - |
A361_RS01470 | 273668..274000 | + | 333 | WP_009336305.1 | anti-sigma factor antagonist | - |
A361_RS01475 | 273997..274470 | + | 474 | WP_009336304.1 | anti-sigma B factor RsbW | - |
A361_RS01480 | 274448..275242 | + | 795 | WP_009336303.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13006.03 Da Isoelectric Point: 4.8998
>T63140 WP_009336311.1 NZ_CP015506:270255-270605 [Bacillus oceanisediminis 2691]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF
Download Length: 351 bp
>T63140 NZ_CP015506:270255-270605 [Bacillus oceanisediminis 2691]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10817.30 Da Isoelectric Point: 7.2025
>AT63140 WP_026041666.1 NZ_CP015506:269969-270250 [Bacillus oceanisediminis 2691]
VSDSSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG
VSDSSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG
Download Length: 282 bp
>AT63140 NZ_CP015506:269969-270250 [Bacillus oceanisediminis 2691]
GTGTCTGATTCCAGCACAACAACAGAGATAATGGTAAAGTTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA
GTGTCTGATTCCAGCACAACAACAGAGATAATGGTAAAGTTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A169FD46 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A160MHA2 |