Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 30186..30712 Replicon plasmid unnamed 1
Accession NZ_CP015501
Organism Klebsiella pneumoniae strain SKGH01

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag A7B01_RS27405 Protein ID WP_000323025.1
Coordinates 30425..30712 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag A7B01_RS27400 Protein ID WP_004196370.1
Coordinates 30186..30425 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7B01_RS33020 25523..25715 - 193 Protein_27 MFS transporter -
A7B01_RS27375 25745..26722 + 978 WP_004196334.1 chromate resistance protein -
A7B01_RS27380 26679..28055 + 1377 WP_004196363.1 chromate efflux transporter -
A7B01_RS27385 28086..28775 - 690 WP_004196322.1 hypothetical protein -
A7B01_RS27390 28789..29526 - 738 WP_008460272.1 HupE/UreJ family protein -
A7B01_RS31500 29570..29935 - 366 WP_009651956.1 hypothetical protein -
A7B01_RS27400 30186..30425 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
A7B01_RS27405 30425..30712 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
A7B01_RS27410 30784..30942 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
A7B01_RS33690 31548..32522 + 975 WP_004196336.1 hypothetical protein -
A7B01_RS27420 32720..33097 - 378 WP_045289277.1 hypothetical protein -
A7B01_RS27425 33424..33720 + 297 WP_094313394.1 hydrogenase expression/formation protein HypD -
A7B01_RS27430 33789..34856 + 1068 WP_049130554.1 hypothetical protein -
A7B01_RS27435 35012..35359 + 348 WP_042935949.1 hypothetical protein -
A7B01_RS27440 35438..35671 + 234 WP_042935952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..281190 281190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T63134 WP_000323025.1 NZ_CP015501:30425-30712 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T63134 NZ_CP015501:30425-30712 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT63134 WP_004196370.1 NZ_CP015501:30186-30425 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT63134 NZ_CP015501:30186-30425 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References