Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3015124..3015688 Replicon chromosome
Accession NZ_CP015495
Organism Mycobacterium avium subsp. paratuberculosis strain MAP/TANUVAS/TN/India/2008

Toxin (Protein)


Gene name vapC Uniprot ID X7VBD8
Locus tag A0V42_RS13680 Protein ID WP_003875391.1
Coordinates 3015124..3015495 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7L5MGM2
Locus tag A0V42_RS22730 Protein ID WP_003875390.1
Coordinates 3015482..3015688 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0V42_RS13640 3010461..3010658 - 198 WP_016706054.1 hypothetical protein -
A0V42_RS13645 3010776..3011459 + 684 WP_003875399.1 hypothetical protein -
A0V42_RS13650 3011464..3011788 - 325 Protein_2734 antibiotic biosynthesis monooxygenase -
A0V42_RS13655 3012199..3012702 - 504 WP_010949693.1 glycoside hydrolase -
A0V42_RS13660 3012880..3013233 - 354 WP_003875396.1 hypothetical protein -
A0V42_RS22725 3013303..3013686 - 384 WP_003875395.1 hypothetical protein -
A0V42_RS13665 3013753..3014151 - 399 WP_003875394.1 VOC family protein -
A0V42_RS13670 3014253..3014528 - 276 WP_003878531.1 hypothetical protein -
A0V42_RS13675 3014584..3015024 - 441 WP_010949694.1 nitroreductase family deazaflavin-dependent oxidoreductase -
A0V42_RS13680 3015124..3015495 - 372 WP_003875391.1 type II toxin-antitoxin system VapC family toxin Toxin
A0V42_RS22730 3015482..3015688 - 207 WP_003875390.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A0V42_RS13685 3015857..3016801 - 945 WP_003875389.1 HNH endonuclease -
A0V42_RS13690 3017001..3018074 - 1074 WP_003878533.1 redox-regulated ATPase YchF -
A0V42_RS13695 3018232..3019413 + 1182 WP_003875387.1 hypothetical protein -
A0V42_RS13700 3019437..3020435 - 999 WP_003875386.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13770.14 Da        Isoelectric Point: 6.6003

>T63111 WP_003875391.1 NZ_CP015495:c3015495-3015124 [Mycobacterium avium subsp. paratuberculosis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Download         Length: 372 bp

>T63111 NZ_CP015495:c3015495-3015124 [Mycobacterium avium subsp. paratuberculosis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGTTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7231.22 Da        Isoelectric Point: 11.0634

>AT63111 WP_003875390.1 NZ_CP015495:c3015688-3015482 [Mycobacterium avium subsp. paratuberculosis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRAPADDSR

Download         Length: 207 bp

>AT63111 NZ_CP015495:c3015688-3015482 [Mycobacterium avium subsp. paratuberculosis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2WB37

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5MGM2

References