Detailed information of TA system TA063107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1616529..1617208
• Replicon: chromosome
• Accession: NZ_CP015483
• Organism: Acinetobacter baumannii strain ORAB01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: SG90_RS07700
• Protein ID: WP_000838146.1
• Coordinates: 1616529..1616711 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: SG90_RS07705
• Protein ID: WP_000966688.1
• Coordinates: 1616804..1617208 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SG90_RS07660	1611603..1612007	+	405	WP_000247948.1	hypothetical protein	-
SG90_RS07665	1611979..1612347	+	369	WP_002055488.1	hypothetical protein	-
SG90_RS07670	1612349..1612747	+	399	WP_044696628.1	hypothetical protein	-
SG90_RS07675	1612749..1612967	+	219	WP_001277687.1	hypothetical protein	-
SG90_RS07680	1613061..1613414	+	354	WP_000064599.1	hypothetical protein	-
SG90_RS07685	1613414..1614648	+	1235	Protein_1501	phage tail protein	-
SG90_RS07690	1614701..1615618	+	918	WP_000094250.1	hypothetical protein	-
SG90_RS07695	1615688..1616203	+	516	WP_001185608.1	hypothetical protein	-
SG90_RS07700	1616529..1616711	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
SG90_RS07705	1616804..1617208	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SG90_RS20055	1617307..1617483	+	177	WP_014466185.1	hypothetical protein	-
SG90_RS07710	1617492..1617815	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
SG90_RS07715	1617847..1618641	+	795	WP_000720608.1	hypothetical protein	-
SG90_RS07720	1618690..1618929	-	240	WP_000763623.1	Arc family DNA-binding protein	-
SG90_RS20060	1619052..1619207	+	156	WP_001103649.1	Arc family DNA-binding protein	-
SG90_RS07725	1619204..1620196	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585259..1640494	55235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T63107 WP_000838146.1 NZ_CP015483:1616529-1616711 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T63107 NZ_CP015483:1616529-1616711 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT63107 WP_000966688.1 NZ_CP015483:1616804-1617208 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT63107 NZ_CP015483:1616804-1617208 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6