Detailed information of TA system TA063104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2798061..2798563
• Replicon: chromosome
• Accession: NZ_CP015455
• Organism: Syntrophotalea acetylenica strain DSM 3246

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1L3GEH1
• Locus tag: A6070_RS13110
• Protein ID: WP_072286193.1
• Coordinates: 2798309..2798563 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L3GEI4
• Locus tag: A6070_RS13105
• Protein ID: WP_072286192.1
• Coordinates: 2798061..2798312 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6070_RS13070	2793227..2793478	+	252	WP_072286186.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
A6070_RS13075	2793486..2793677	+	192	WP_083558848.1	Txe/YoeB family addiction module toxin	-
A6070_RS13080	2793780..2794262	-	483	WP_072286187.1	hypothetical protein	-
A6070_RS13085	2794607..2795971	+	1365	WP_072286188.1	ISNCY family transposase	-
A6070_RS13090	2796062..2796430	-	369	WP_072286189.1	hypothetical protein	-
A6070_RS13095	2796557..2797180	-	624	WP_072286190.1	cold shock and DUF1294 domain-containing protein	-
A6070_RS13100	2797321..2797881	-	561	WP_072286191.1	hypothetical protein	-
A6070_RS13105	2798061..2798312	+	252	WP_072286192.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A6070_RS13110	2798309..2798563	+	255	WP_072286193.1	Txe/YoeB family addiction module toxin	Toxin
A6070_RS13115	2798734..2798985	+	252	WP_072286192.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
A6070_RS13120	2798982..2799236	+	255	WP_072286193.1	Txe/YoeB family addiction module toxin	-
A6070_RS13125	2799264..2799614	-	351	WP_072286194.1	putative addiction module antidote protein	-
A6070_RS13130	2799623..2799913	-	291	WP_072286195.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A6070_RS13135	2800068..2800418	-	351	WP_072286196.1	n-acetylglutamate synthase	-
A6070_RS13140	2800599..2801696	-	1098	WP_083558496.1	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2787467..2816183	28716
	-	flank	IS/Tn	-	-	2794607..2795971	1364
	-	inside	Integron	-	-	2796557..2801696	5139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10188.61 Da
• Isoelectric Point: 9.5746

>T63104 WP_072286193.1 NZ_CP015455:2798309-2798563 [Syntrophotalea acetylenica]
MKLVFSENAWDDYQYWLRTDKKLLKRLNSLIRDIQRSPYEGIGKPEPLKHGLSGYWSRRITDEHRIVYKVDDDAIFIAQA
RYHY

Nucleotide

• Length: 255 bp

>T63104 NZ_CP015455:2798309-2798563 [Syntrophotalea acetylenica]
ATGAAGCTGGTATTTTCCGAAAATGCCTGGGACGATTACCAATATTGGCTGCGAACCGACAAAAAACTCCTCAAACGCCT
CAACTCGCTAATTCGGGATATTCAACGCTCTCCATACGAAGGGATCGGTAAACCCGAACCTCTCAAACACGGTTTATCTG
GCTATTGGTCACGTCGCATTACCGACGAGCACCGCATTGTCTATAAAGTCGATGACGATGCAATTTTCATCGCCCAGGCA
AGATACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9355.59 Da
• Isoelectric Point: 4.6892

>AT63104 WP_072286192.1 NZ_CP015455:2798061-2798312 [Syntrophotalea acetylenica]
MEAISYTKARSNLAKAMEKVCEDHSPIIITRRNENSVVMISLEDYQALEETAYLLRSPKNARRLLESIAELESGGGVERE
LSE

Nucleotide

• Length: 252 bp

>AT63104 NZ_CP015455:2798061-2798312 [Syntrophotalea acetylenica]
ATGGAAGCAATTTCTTATACCAAAGCTCGCAGCAACTTGGCCAAGGCCATGGAAAAAGTCTGTGAGGACCACTCCCCTAT
CATTATCACCCGTCGCAATGAAAACTCGGTTGTGATGATATCCCTTGAAGACTACCAGGCCCTTGAAGAAACGGCTTATC
TGCTGCGAAGTCCTAAAAACGCCCGGCGACTCCTGGAATCAATTGCTGAACTTGAATCCGGCGGAGGAGTAGAGCGGGAG
TTGAGCGAATGA

Structures

Toxin

• AlphaFold DB: A0A1L3GEH1

Antitoxin

• AlphaFold DB: A0A1L3GEI4