Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1390452..1390932 Replicon chromosome
Accession NZ_CP015455
Organism Syntrophotalea acetylenica strain DSM 3246

Toxin (Protein)


Gene name - Uniprot ID A0A1L3GIE2
Locus tag A6070_RS06365 Protein ID WP_072287545.1
Coordinates 1390663..1390932 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1L3GIF2
Locus tag A6070_RS06360 Protein ID WP_072287544.1
Coordinates 1390452..1390682 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6070_RS06310 1385599..1385898 - 300 WP_072287536.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6070_RS06315 1385895..1386167 - 273 WP_072287537.1 prevent-host-death protein -
A6070_RS06320 1386438..1386659 + 222 WP_072287538.1 addiction module protein -
A6070_RS06325 1386656..1386952 + 297 WP_072287539.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6070_RS15695 1386993..1387220 - 228 WP_072287540.1 hypothetical protein -
A6070_RS06335 1387198..1388532 + 1335 Protein_1231 IS21 family transposase -
A6070_RS06340 1388714..1389103 + 390 WP_072287541.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6070_RS06345 1389084..1389407 + 324 WP_072287542.1 DNA-binding transcriptional regulator -
A6070_RS06350 1389716..1389970 + 255 WP_072288168.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A6070_RS06360 1390452..1390682 - 231 WP_072287544.1 CopG family transcriptional regulator Antitoxin
A6070_RS06365 1390663..1390932 - 270 WP_072287545.1 BrnT family toxin Toxin
A6070_RS06370 1391423..1391716 + 294 WP_072287546.1 nucleotidyltransferase family protein -
A6070_RS06375 1391706..1392044 + 339 WP_072287547.1 DUF86 domain-containing protein -
A6070_RS06385 1392458..1392685 + 228 WP_072287548.1 ribbon-helix-helix protein, CopG family -
A6070_RS06390 1392666..1392962 + 297 WP_083558789.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6070_RS06395 1393271..1393600 - 330 WP_072287549.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6070_RS06400 1393597..1393884 - 288 WP_072287550.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A6070_RS06405 1394111..1394482 - 372 WP_083558790.1 DUF86 domain-containing protein -
A6070_RS06410 1394479..1394769 - 291 WP_072287551.1 nucleotidyltransferase family protein -
A6070_RS06415 1395050..1395277 + 228 WP_072287552.1 ribbon-helix-helix protein, CopG family -
A6070_RS06420 1395258..1395599 + 342 WP_145926437.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10375.93 Da        Isoelectric Point: 9.9115

>T63102 WP_072287545.1 NZ_CP015455:c1390932-1390663 [Syntrophotalea acetylenica]
MRFKFDPQKSASNKAKHGIDFDEAQALWADPDLLEIPARTIDEPRFLILGKIDGKYWSGVITYRRNVIRIISIRRSRPEE
VALYENKSL

Download         Length: 270 bp

>T63102 NZ_CP015455:c1390932-1390663 [Syntrophotalea acetylenica]
ATGAGATTCAAATTCGACCCTCAAAAAAGTGCTTCCAATAAGGCCAAACACGGCATCGATTTCGACGAAGCTCAAGCACT
CTGGGCCGATCCGGATCTGCTGGAAATCCCCGCTCGAACCATCGATGAGCCCCGCTTCTTAATTCTCGGTAAAATCGATG
GCAAATATTGGTCAGGAGTCATCACTTACCGCCGGAACGTCATCCGTATCATTTCCATCCGGCGTTCCCGCCCGGAAGAG
GTCGCCCTTTATGAAAACAAAAGCTTGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8954.21 Da        Isoelectric Point: 5.1578

>AT63102 WP_072287544.1 NZ_CP015455:c1390682-1390452 [Syntrophotalea acetylenica]
MKTKACDFDKKFDDGEDITSDLDLDNARRPEYEQKRVNVDFPLWMIQSLDREAKRLGVPRQAIIKLWIADRLEKAS

Download         Length: 231 bp

>AT63102 NZ_CP015455:c1390682-1390452 [Syntrophotalea acetylenica]
ATGAAAACAAAAGCTTGTGATTTCGACAAAAAATTCGACGATGGCGAAGATATCACCTCGGATCTGGACCTGGATAACGC
ACGCCGTCCTGAATATGAGCAAAAACGGGTCAATGTCGATTTCCCGCTCTGGATGATTCAGTCTCTTGATCGAGAGGCCA
AGCGACTTGGTGTGCCGCGCCAGGCAATCATCAAATTATGGATTGCGGACCGTCTGGAGAAAGCATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L3GIE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L3GIF2

References