Detailed information of TA system TA063100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1384120..1384645
• Replicon: chromosome
• Accession: NZ_CP015455
• Organism: Syntrophotalea acetylenica strain DSM 3246

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1L3GIE6
• Locus tag: A6070_RS06290
• Protein ID: WP_072287532.1
• Coordinates: 1384120..1384410 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L3GIG4
• Locus tag: A6070_RS06295
• Protein ID: WP_072287533.1
• Coordinates: 1384400..1384645 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6070_RS06275	1380668..1381027	-	360	WP_072287529.1	four helix bundle protein	-
A6070_RS06280	1381171..1382520	+	1350	WP_072287530.1	phosphomannomutase	-
A6070_RS06285	1382541..1383449	+	909	WP_072287531.1	hypothetical protein	-
A6070_RS06290	1384120..1384410	-	291	WP_072287532.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6070_RS06295	1384400..1384645	-	246	WP_072287533.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A6070_RS06300	1384867..1385094	+	228	WP_072287534.1	CopG family transcriptional regulator	-
A6070_RS06305	1385078..1385344	+	267	WP_072287535.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A6070_RS06310	1385599..1385898	-	300	WP_072287536.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A6070_RS06315	1385895..1386167	-	273	WP_072287537.1	prevent-host-death protein	-
A6070_RS06320	1386438..1386659	+	222	WP_072287538.1	addiction module protein	-
A6070_RS06325	1386656..1386952	+	297	WP_072287539.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A6070_RS15695	1386993..1387220	-	228	WP_072287540.1	hypothetical protein	-
A6070_RS06335	1387198..1388532	+	1335	Protein_1231	IS21 family transposase	-
A6070_RS06340	1388714..1389103	+	390	WP_072287541.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A6070_RS06345	1389084..1389407	+	324	WP_072287542.1	DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	gmd / manB	1351806..1386167	34361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10993.92 Da
• Isoelectric Point: 10.6677

>T63100 WP_072287532.1 NZ_CP015455:c1384410-1384120 [Syntrophotalea acetylenica]
MSYSLEFKGSALKEWKKLDGGIREQFKKKLAERLGRPHVEAARLKGIPDCYKIKLKNAGYRLVYQVDDNRVVVIVVAVGK
RENLSVYKTAGRRVKD

Nucleotide

• Length: 291 bp

>T63100 NZ_CP015455:c1384410-1384120 [Syntrophotalea acetylenica]
ATGAGTTATAGCCTTGAATTCAAAGGATCCGCTCTGAAGGAATGGAAAAAACTGGATGGTGGAATCCGGGAGCAATTCAA
GAAAAAGCTGGCGGAACGCCTCGGCAGACCTCATGTCGAAGCTGCCAGACTTAAGGGGATACCTGACTGCTACAAGATCA
AGCTGAAAAATGCCGGTTACCGGCTGGTTTACCAGGTGGACGACAACCGGGTGGTAGTTATCGTCGTAGCAGTGGGTAAG
CGGGAAAATCTATCGGTATACAAAACGGCGGGAAGGCGGGTAAAGGATTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9157.47 Da
• Isoelectric Point: 4.8481

>AT63100 WP_072287533.1 NZ_CP015455:c1384645-1384400 [Syntrophotalea acetylenica]
MERLYARASVSISDLKKNPSRIINEAEGTPVAILNHNKPSAYLVPAKAFEALMEQLEDYELSRLVKEREKESTIPVSLDE
L

Nucleotide

• Length: 246 bp

>AT63100 NZ_CP015455:c1384645-1384400 [Syntrophotalea acetylenica]
ATGGAACGTCTTTATGCCCGTGCATCAGTCAGCATCAGCGATCTGAAAAAGAACCCTTCCCGGATCATCAACGAAGCCGA
GGGCACGCCGGTCGCAATTTTGAATCACAACAAACCCAGCGCATACCTCGTACCTGCCAAAGCCTTTGAGGCCCTTATGG
AGCAGCTCGAGGATTATGAACTCTCCCGCCTGGTCAAAGAGCGGGAAAAGGAATCCACAATCCCGGTATCGCTCGATGAG
TTATAG

Structures

Toxin

• AlphaFold DB: A0A1L3GIE6

Antitoxin

• AlphaFold DB: A0A1L3GIG4