63086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2216216..2216841 Replicon chromosome
Accession NZ_CP015447
Organism Staphylococcus aureus strain M92

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag A6V38_RS11795 Protein ID WP_001179607.1
Coordinates 2216216..2216611 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag A6V38_RS11800 Protein ID WP_000258939.1
Coordinates 2216611..2216841 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V38_RS11755 2211771..2212211 - 441 Protein_2172 GNAT family N-acetyltransferase -
A6V38_RS11760 2212186..2212437 - 252 WP_002505594.1 hypothetical protein -
A6V38_RS11765 2212434..2213069 - 636 Protein_2174 aminoglycoside 6-adenylyltransferase -
A6V38_RS11770 2213284..2214006 - 723 WP_001043218.1 hypothetical protein -
A6V38_RS11775 2214115..2214915 - 801 WP_000686449.1 metallophosphoesterase -
A6V38_RS11780 2214919..2215413 - 495 WP_000280790.1 hypothetical protein -
A6V38_RS11785 2215470..2215739 - 270 WP_000755772.1 hypothetical protein -
A6V38_RS11790 2215723..2215914 - 192 WP_032605691.1 hypothetical protein -
A6V38_RS11795 2216216..2216611 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
A6V38_RS11800 2216611..2216841 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
A6V38_RS11805 2217017..2217538 - 522 WP_000639078.1 metallophosphoesterase -
A6V38_RS11810 2217538..2218188 - 651 WP_000411528.1 hypothetical protein -
A6V38_RS11815 2218188..2218505 - 318 WP_001807410.1 hypothetical protein -
A6V38_RS11820 2218498..2219223 - 726 WP_000197304.1 metallophosphoesterase -
A6V38_RS11825 2219223..2219444 - 222 WP_000829423.1 hypothetical protein -
A6V38_RS16175 2219464..2219640 - 177 WP_000063384.1 hypothetical protein -
A6V38_RS11830 2219633..2220175 - 543 WP_000858632.1 hypothetical protein -
A6V38_RS11835 2220190..2220462 - 273 WP_000691100.1 hypothetical protein -
A6V38_RS11840 2220488..2220643 - 156 WP_000792995.1 transcriptional regulator -
A6V38_RS16180 2220757..2220924 - 168 WP_000312832.1 hypothetical protein -
A6V38_RS11845 2220940..2221125 - 186 WP_001187008.1 hypothetical protein -
A6V38_RS11850 2221110..2221289 - 180 WP_000401832.1 hypothetical protein -
A6V38_RS11855 2221303..2221785 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2177292..2304544 127252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T63086 WP_001179607.1 NZ_CP015447:c2216611-2216216 [Staphylococcus aureus]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T63086 NZ_CP015447:c2216611-2216216 [Staphylococcus aureus]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT63086 WP_000258939.1 NZ_CP015447:c2216841-2216611 [Staphylococcus aureus]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT63086 NZ_CP015447:c2216841-2216611 [Staphylococcus aureus]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References