Detailed information of TA system TA063081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 2037848..2038639
• Replicon: chromosome
• Accession: NZ_CP015447
• Organism: Staphylococcus aureus strain M92

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: A6V38_RS10595
• Protein ID: WP_000525003.1
• Coordinates: 2038175..2038639 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: A6V38_RS10590
• Protein ID: WP_000333630.1
• Coordinates: 2037848..2038162 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6V38_RS10540	2034096..2034359	-	264	WP_001205732.1	hypothetical protein	-
A6V38_RS10545	2034368..2034628	-	261	WP_031825655.1	DUF1108 family protein	-
A6V38_RS10550	2034633..2034935	-	303	WP_044131919.1	DUF2482 family protein	-
A6V38_RS10555	2035029..2035190	-	162	WP_000048130.1	DUF1270 family protein	-
A6V38_RS10560	2035183..2035404	-	222	WP_000594790.1	hypothetical protein	-
A6V38_RS10565	2035475..2035705	+	231	WP_000395455.1	hypothetical protein	-
A6V38_RS10570	2035881..2036624	-	744	WP_001148594.1	phage antirepressor KilAC domain-containing protein	-
A6V38_RS10575	2036684..2037166	+	483	WP_000394410.1	hypothetical protein	-
A6V38_RS10580	2037267..2037446	-	180	WP_000438352.1	hypothetical protein	-
A6V38_RS10585	2037460..2037696	-	237	WP_001121116.1	helix-turn-helix domain-containing protein	-
A6V38_RS10590	2037848..2038162	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
A6V38_RS10595	2038175..2038639	+	465	WP_000525003.1	hypothetical protein	Toxin
A6V38_RS10600	2038671..2039603	+	933	WP_031837133.1	hypothetical protein	-
A6V38_RS10605	2039583..2039762	-	180	WP_000337827.1	hypothetical protein	-
A6V38_RS10610	2039875..2040921	+	1047	WP_001145722.1	site-specific integrase	-
A6V38_RS10615	2040966..2042111	+	1146	WP_001245441.1	radical SAM/CxCxxxxC motif protein YfkAB	-
A6V38_RS10620	2042371..2042901	-	531	WP_000184383.1	acyl-CoA thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1996593..2040921	44328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18156.52 Da
• Isoelectric Point: 4.7927

>T63081 WP_000525003.1 NZ_CP015447:2038175-2038639 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID

Nucleotide

• Length: 465 bp

>T63081 NZ_CP015447:2038175-2038639 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCACATTGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT63081 WP_000333630.1 NZ_CP015447:2037848-2038162 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT63081 NZ_CP015447:2037848-2038162 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0