Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 899181..899658 Replicon chromosome
Accession NZ_CP015447
Organism Staphylococcus aureus strain M92

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag A6V38_RS04535 Protein ID WP_000052078.1
Coordinates 899181..899369 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A6V38_RS04540 Protein ID WP_001059690.1
Coordinates 899398..899658 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V38_RS04505 895221..895691 + 471 WP_000824472.1 hypothetical protein -
A6V38_RS04510 896032..896718 + 687 WP_001548082.1 thermonuclease family protein -
A6V38_RS04515 897075..897275 + 201 WP_001059082.1 cold-shock protein -
A6V38_RS04520 897772..897990 - 219 WP_000005886.1 hypothetical protein -
A6V38_RS04525 898052..898336 - 285 WP_001004395.1 hypothetical protein -
A6V38_RS04530 898424..898993 - 570 WP_001106654.1 hypothetical protein -
A6V38_RS04535 899181..899369 - 189 WP_000052078.1 hypothetical protein Toxin
A6V38_RS04540 899398..899658 - 261 WP_001059690.1 hypothetical protein Antitoxin
A6V38_RS04545 899999..900202 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A6V38_RS04550 900199..900435 - 237 WP_000368687.1 hypothetical protein -
A6V38_RS04555 900660..901241 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
A6V38_RS04560 901314..901931 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A6V38_RS04565 902086..902580 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
A6V38_RS04570 902979..903401 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
A6V38_RS04575 903549..904265 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 893864..923926 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin HigB-like

(12-92)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T63076 WP_000052078.1 NZ_CP015447:c899369-899181 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T63076 NZ_CP015447:c899369-899181 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT63076 WP_001059690.1 NZ_CP015447:c899658-899398 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT63076 NZ_CP015447:c899658-899398 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References