Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3069914..3070550 Replicon chromosome
Accession NZ_CP015436
Organism Anoxybacillus sp. B7M1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GFC29_RS14820 Protein ID WP_003253417.1
Coordinates 3070200..3070550 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160FEC9
Locus tag GFC29_RS14815 Protein ID WP_044741999.1
Coordinates 3069914..3070195 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFC29_RS14795 3066035..3066637 - 603 WP_044742003.1 rhomboid family intramembrane serine protease -
GFC29_RS14800 3066935..3067297 + 363 WP_044742002.1 holo-ACP synthase -
GFC29_RS14805 3067388..3068401 + 1014 WP_044742001.1 outer membrane lipoprotein carrier protein LolA -
GFC29_RS14810 3068606..3069775 + 1170 WP_044742000.1 alanine racemase -
GFC29_RS14815 3069914..3070195 + 282 WP_044741999.1 hypothetical protein Antitoxin
GFC29_RS14820 3070200..3070550 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GFC29_RS14825 3070679..3072844 + 2166 WP_044741998.1 RNA-binding transcriptional accessory protein -
GFC29_RS19665 3073096..3073221 - 126 WP_139788175.1 cortex morphogenetic protein CmpA -
GFC29_RS14830 3073305..3073781 + 477 WP_044741997.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T63073 WP_003253417.1 NZ_CP015436:3070200-3070550 [Anoxybacillus sp. B7M1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T63073 NZ_CP015436:3070200-3070550 [Anoxybacillus sp. B7M1]
TTGATTGTTAAGCGTGGCGACGTTTATTTCGCGGACCTTTCCCCGGTAGTTGGTTCGGAGCAAGGAGGCGTGCGTCCGGT
ATTAGTTATTCAAAACGACATCGGAAATCGGTTTAGTCCAACAGTTATTGTGGCAGCTATAACAGCGCAGATCCAGAAAG
CCAAATTGCCCACCCACGTGGAAATTGATGCGAAACGGTATGGATTTGAACGAGATTCCGTCATTCTTTTAGAGCAAATT
CGTACGATTGACAAACAAAGGCTCACGGACAAGATTACGCACTTAGATGACGAAATGATGGATAAAGTAGATGAGGCGCT
CCAAATCAGTCTAGGGCTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10644.18 Da        Isoelectric Point: 7.2025

>AT63073 WP_044741999.1 NZ_CP015436:3069914-3070195 [Anoxybacillus sp. B7M1]
MSESSATTEIVVRLPQALLTELDGLVKQENGNRNDLIYQATKMYIRERKKRHIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT63073 NZ_CP015436:3069914-3070195 [Anoxybacillus sp. B7M1]
ATGTCTGAATCGAGCGCAACAACAGAAATCGTCGTTCGCTTACCCCAAGCATTGTTGACTGAGTTAGATGGTCTTGTCAA
GCAAGAAAACGGTAATCGAAACGACCTCATTTACCAAGCGACTAAAATGTACATTCGTGAACGAAAAAAGCGGCACATTC
GCGAGGCGATGAGACGCGGTTACATGGAAATGGCGAAAATCAACTTGTCGATTGCATCGGAAGCGTTTCTTGCGGAATAT
GAAGCCGACCATACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A160FEC9

References