Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2389286..2389922 Replicon chromosome
Accession NZ_CP015435
Organism Anoxybacillus sp. B2M1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GFC28_RS11595 Protein ID WP_003253417.1
Coordinates 2389286..2389636 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160FEC9
Locus tag GFC28_RS11600 Protein ID WP_044741999.1
Coordinates 2389641..2389922 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFC28_RS11585 2386055..2386531 - 477 WP_044741997.1 SprT family protein -
GFC28_RS19340 2386615..2386740 + 126 WP_139788175.1 cortex morphogenetic protein CmpA -
GFC28_RS11590 2386992..2389157 - 2166 WP_044741998.1 RNA-binding transcriptional accessory protein -
GFC28_RS11595 2389286..2389636 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GFC28_RS11600 2389641..2389922 - 282 WP_044741999.1 hypothetical protein Antitoxin
GFC28_RS11605 2390061..2391230 - 1170 WP_044742000.1 alanine racemase -
GFC28_RS11610 2391435..2392448 - 1014 WP_044742001.1 outer membrane lipoprotein carrier protein LolA -
GFC28_RS11615 2392539..2392901 - 363 WP_044742002.1 holo-ACP synthase -
GFC28_RS11620 2393199..2393801 + 603 WP_044742003.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T63069 WP_003253417.1 NZ_CP015435:c2389636-2389286 [Anoxybacillus sp. B2M1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T63069 NZ_CP015435:c2389636-2389286 [Anoxybacillus sp. B2M1]
TTGATTGTTAAGCGTGGCGACGTTTATTTCGCGGACCTTTCCCCGGTAGTTGGTTCGGAGCAAGGAGGCGTGCGTCCGGT
ATTAGTTATTCAAAACGACATCGGAAATCGGTTTAGTCCAACAGTTATTGTGGCAGCTATAACAGCGCAGATCCAGAAAG
CCAAATTGCCCACCCACGTGGAAATTGATGCGAAACGGTATGGATTTGAACGAGATTCCGTCATTCTTTTAGAGCAAATT
CGTACGATTGACAAACAAAGGCTCACGGACAAGATTACGCACTTAGATGACGAAATGATGGATAAAGTAGATGAGGCGCT
CCAAATCAGTCTAGGGCTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10644.18 Da        Isoelectric Point: 7.2025

>AT63069 WP_044741999.1 NZ_CP015435:c2389922-2389641 [Anoxybacillus sp. B2M1]
MSESSATTEIVVRLPQALLTELDGLVKQENGNRNDLIYQATKMYIRERKKRHIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT63069 NZ_CP015435:c2389922-2389641 [Anoxybacillus sp. B2M1]
ATGTCTGAATCGAGCGCAACAACAGAAATCGTCGTTCGCTTACCCCAAGCATTGTTGACTGAGTTAGATGGTCTTGTCAA
GCAAGAAAACGGTAATCGAAACGACCTCATTTACCAAGCGACTAAAATGTACATTCGTGAACGAAAAAAGCGGCACATTC
GCGAGGCGATGAGACGCGGTTACATGGAAATGGCGAAAATCAACTTGTCGATTGCATCGGAAGCGTTTCTTGCGGAATAT
GAAGCCGACCATACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A160FEC9

References