Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 49571..50195 Replicon plasmid unnamed
Accession NZ_CP015422
Organism Rhodovulum sulfidophilum strain SNK001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A6024_RS19110 Protein ID WP_042465586.1
Coordinates 49791..50195 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A6024_RS19105 Protein ID WP_042465583.1
Coordinates 49571..49801 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6024_RS19085 45671..46177 - 507 WP_042465573.1 TRAP transporter small permease -
A6024_RS19090 46278..47435 - 1158 WP_042465576.1 TRAP transporter substrate-binding protein -
A6024_RS19095 47479..47703 - 225 WP_042465579.1 hypothetical protein -
A6024_RS19100 47817..48860 + 1044 WP_042465581.1 LacI family DNA-binding transcriptional regulator -
A6024_RS19105 49571..49801 + 231 WP_042465583.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A6024_RS19110 49791..50195 + 405 WP_042465586.1 PIN domain-containing protein Toxin
A6024_RS19115 50304..50975 + 672 WP_042465589.1 SDR family NAD(P)-dependent oxidoreductase -
A6024_RS19120 50989..51834 - 846 WP_155734912.1 DMT family transporter -
A6024_RS19125 52167..52787 + 621 WP_042465595.1 exopolysaccharide biosynthesis protein -
A6024_RS19130 53271..53894 + 624 WP_042465597.1 RNA ligase family protein -
A6024_RS19135 54407..55048 - 642 WP_042465600.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..113522 113522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14622.72 Da        Isoelectric Point: 4.3913

>T63066 WP_042465586.1 NZ_CP015422:49791-50195 [Rhodovulum sulfidophilum]
MPADFFDTNVILYLLDDGPKADRSEALLAKGGTISVQVLNEALVNCLRKARMSHDEAGEFLFGIRDLCETVELTVDTHDV
GRALAARYKLSVYDSMIVAAALLSGCTRLWSEDMQDGLTVEGRLKIVNPFADAA

Download         Length: 405 bp

>T63066 NZ_CP015422:49791-50195 [Rhodovulum sulfidophilum]
ATGCCCGCTGACTTCTTCGACACCAACGTCATCCTCTACCTGCTGGACGACGGGCCCAAGGCCGACCGGTCCGAGGCGCT
GCTGGCTAAGGGCGGCACGATCAGCGTCCAGGTGCTGAACGAGGCGCTGGTGAACTGCCTGCGCAAGGCCCGGATGAGCC
ATGACGAGGCGGGCGAATTCCTGTTCGGGATCCGCGATCTCTGCGAGACGGTCGAGCTGACCGTCGACACCCATGATGTC
GGCCGCGCGCTGGCCGCCCGCTACAAGCTGTCGGTCTACGATTCGATGATCGTCGCCGCGGCGCTTCTCAGCGGCTGCAC
CAGGCTCTGGTCCGAGGACATGCAAGACGGGCTGACCGTCGAGGGGCGGCTGAAGATCGTCAACCCCTTCGCCGACGCCG
CCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8490.63 Da        Isoelectric Point: 11.8979

>AT63066 WP_042465583.1 NZ_CP015422:49571-49801 [Rhodovulum sulfidophilum]
MQIARWGNSLAVRLPADLVRTLGLREGDRIELEPSGEGRLAVSRHPRADEVLSGLRRFRGRLASEDRLSRDAANAR

Download         Length: 231 bp

>AT63066 NZ_CP015422:49571-49801 [Rhodovulum sulfidophilum]
ATGCAGATCGCCAGATGGGGAAATTCGCTTGCCGTCCGCCTGCCCGCGGATCTGGTCCGGACCCTCGGCCTGCGCGAGGG
CGACCGGATCGAGCTGGAGCCCTCGGGCGAGGGTCGGCTTGCAGTCAGCCGCCATCCCCGTGCCGATGAGGTGCTGTCAG
GGCTGCGCCGGTTCCGCGGCCGTCTGGCGTCCGAAGACCGGCTGAGCCGCGACGCGGCCAATGCCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References