Detailed information of TA system TA063065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3083139..3083730
• Replicon: chromosome
• Accession: NZ_CP015421
• Organism: Rhodovulum sulfidophilum strain SNK001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A6024_RS14505
• Protein ID: WP_042464994.1
• Coordinates: 3083548..3083730 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A160E2U9
• Locus tag: A6024_RS14500
• Protein ID: WP_042461682.1
• Coordinates: 3083139..3083531 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6024_RS14470	3079353..3079640	+	288	WP_081251948.1	hypothetical protein	-
A6024_RS14475	3079662..3080300	-	639	WP_063491318.1	hypothetical protein	-
A6024_RS14480	3080350..3080820	+	471	Protein_2950	phage terminase large subunit family protein	-
A6024_RS20530	3080842..3081315	-	474	Protein_2951	tetratricopeptide repeat protein	-
A6024_RS20980	3081221..3082051	-	831	WP_042462605.1	hypothetical protein	-
A6024_RS20540	3082178..3082312	+	135	Protein_2953	transposase	-
A6024_RS14490	3082393..3082614	-	222	WP_042462606.1	zinc finger-like domain-containing protein	-
A6024_RS14495	3082614..3082883	-	270	Protein_2955	hypothetical protein	-
A6024_RS14500	3083139..3083531	-	393	WP_042461682.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6024_RS14505	3083548..3083730	-	183	WP_042464994.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6024_RS14510	3083827..3084351	+	525	WP_063491320.1	hypothetical protein	-
A6024_RS14515	3084351..3084758	+	408	WP_042462612.1	hypothetical protein	-
A6024_RS14520	3084743..3085657	+	915	WP_155734824.1	hypothetical protein	-
A6024_RS14525	3086364..3086825	+	462	WP_042462616.1	SAM-dependent methyltransferase	-
A6024_RS14530	3086822..3087868	+	1047	WP_196760188.1	iron ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3077201..3085657	8456

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6968.15 Da
• Isoelectric Point: 11.0108

>T63065 WP_042464994.1 NZ_CP015421:c3083730-3083548 [Rhodovulum sulfidophilum]
METNSRKIVKRLEQDGFELVKVTGSHHKFRKGDRIVTIPHPKKDLPIGTVRNIYKQAGWL

Nucleotide

• Length: 183 bp

>T63065 NZ_CP015421:c3083730-3083548 [Rhodovulum sulfidophilum]
CTGGAGACCAACAGCCGCAAGATCGTCAAGCGTCTCGAGCAAGACGGCTTCGAGCTGGTGAAGGTCACCGGGTCGCACCA
CAAGTTTCGCAAGGGCGACAGGATCGTGACGATCCCCCACCCGAAGAAGGACCTGCCCATCGGCACGGTCCGCAACATCT
ACAAACAGGCCGGTTGGCTGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13935.68 Da
• Isoelectric Point: 4.4135

>AT63065 WP_042461682.1 NZ_CP015421:c3083531-3083139 [Rhodovulum sulfidophilum]
MRHYIGVVHQEDDSAFGIHFPDVPGCFSAADALDDLLANASEALALHLEDEILPEARSLDAVRADSDVARDLEAGAFLLA
VPFFRLSGRTAKANITMDAGLLAAIDQTAKERGLTRSAFLADLARREITG

Nucleotide

• Length: 393 bp

>AT63065 NZ_CP015421:c3083531-3083139 [Rhodovulum sulfidophilum]
ATGCGTCACTACATCGGCGTCGTGCACCAGGAAGACGACAGCGCCTTCGGCATCCATTTCCCCGACGTGCCCGGCTGCTT
CTCGGCGGCCGATGCCCTCGACGATCTTCTGGCCAATGCCAGCGAGGCGCTCGCGCTTCATCTCGAGGACGAGATCCTGC
CCGAGGCGCGCAGCCTCGATGCCGTTCGGGCCGATAGCGACGTGGCCCGTGACCTCGAGGCCGGGGCGTTCCTTCTGGCG
GTGCCGTTCTTCCGGCTGAGCGGGCGAACCGCCAAGGCGAATATCACCATGGATGCGGGGCTGCTGGCGGCCATCGACCA
GACGGCGAAAGAGCGCGGGCTGACCCGCTCGGCCTTCCTGGCCGATCTGGCGCGGCGCGAGATCACCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A160E2U9