Detailed information of TA system TA063064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2438712..2439303
• Replicon: chromosome
• Accession: NZ_CP015421
• Organism: Rhodovulum sulfidophilum strain SNK001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A6024_RS11560
• Protein ID: WP_042464994.1
• Coordinates: 2438712..2438894 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A160E2U9
• Locus tag: A6024_RS11565
• Protein ID: WP_042461682.1
• Coordinates: 2438911..2439303 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6024_RS11535	2433924..2434211	-	288	WP_042461673.1	hypothetical protein	-
A6024_RS11540	2434246..2435055	-	810	WP_042462587.1	hypothetical protein	-
A6024_RS11545	2435063..2437702	-	2640	WP_063490916.1	hypothetical protein	-
A6024_RS11550	2437687..2438094	-	408	WP_042461678.1	hypothetical protein	-
A6024_RS11555	2438091..2438615	-	525	WP_042461680.1	hypothetical protein	-
A6024_RS11560	2438712..2438894	+	183	WP_042464994.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6024_RS11565	2438911..2439303	+	393	WP_042461682.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6024_RS11570	2439312..2439902	-	591	WP_063490917.1	hypothetical protein	-
A6024_RS11575	2439902..2440585	-	684	WP_052678017.1	hypothetical protein	-
A6024_RS11580	2440563..2441114	+	552	Protein_2357	hypothetical protein	-
A6024_RS11585	2441114..2441404	+	291	WP_042461688.1	hypothetical protein	-
A6024_RS11590	2441552..2442691	+	1140	WP_042461690.1	hypothetical protein	-
A6024_RS11595	2443291..2443755	+	465	WP_042461692.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2432171..2484460	52289

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6968.15 Da
• Isoelectric Point: 11.0108

>T63064 WP_042464994.1 NZ_CP015421:2438712-2438894 [Rhodovulum sulfidophilum]
METNSRKIVKRLEQDGFELVKVTGSHHKFRKGDRIVTIPHPKKDLPIGTVRNIYKQAGWL

Nucleotide

• Length: 183 bp

>T63064 NZ_CP015421:2438712-2438894 [Rhodovulum sulfidophilum]
CTGGAGACCAACAGCCGCAAGATCGTCAAGCGTCTCGAGCAAGACGGCTTCGAGCTGGTGAAGGTCACCGGGTCGCACCA
CAAGTTTCGCAAGGGCGACAGGATCGTGACGATCCCCCACCCGAAGAAGGACCTGCCCATCGGCACGGTCCGCAACATCT
ACAAACAGGCCGGTTGGCTGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13935.68 Da
• Isoelectric Point: 4.4135

>AT63064 WP_042461682.1 NZ_CP015421:2438911-2439303 [Rhodovulum sulfidophilum]
MRHYIGVVHQEDDSAFGIHFPDVPGCFSAADALDDLLANASEALALHLEDEILPEARSLDAVRADSDVARDLEAGAFLLA
VPFFRLSGRTAKANITMDAGLLAAIDQTAKERGLTRSAFLADLARREITG

Nucleotide

• Length: 393 bp

>AT63064 NZ_CP015421:2438911-2439303 [Rhodovulum sulfidophilum]
ATGCGTCACTACATCGGCGTCGTGCACCAGGAAGACGACAGCGCCTTCGGCATCCATTTCCCCGACGTGCCCGGCTGCTT
CTCGGCCGCCGATGCGCTCGACGATCTTCTGGCCAATGCCAGCGAGGCGCTCGCGCTTCATCTCGAGGACGAGATCCTGC
CCGAGGCGCGCAGCCTCGATGCCGTTCGGGCCGACAGCGACGTGGCCCGTGACCTCGAGGCCGGGGCGTTCCTTCTGGCG
GTGCCGTTCTTCCGGCTGAGCGGGCGAACCGCCAAGGCGAATATCACCATGGATGCGGGGCTGCTGGCGGCCATCGACCA
GACGGCGAAAGAGCGCGGGCTGACCCGCTCGGCCTTCCTGGCCGATCTGGCGCGGCGCGAGATCACCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A160E2U9