Detailed information of TA system TA063062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 58733..59394
• Replicon: plasmid unnamed2
• Accession: NZ_CP015420
• Organism: Rhodovulum sulfidophilum DSM 1374

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0D6B8Q0
• Locus tag: A6W98_RS19860
• Protein ID: WP_042465871.1
• Coordinates: 58993..59394 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A6W98_RS19855
• Protein ID: WP_042465868.1
• Coordinates: 58733..58993 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6W98_RS19840	54452..56818	+	2367	WP_052678179.1	response regulator	-
A6W98_RS19845	56815..57498	+	684	WP_042465864.1	response regulator transcription factor	-
A6W98_RS19850	57618..58640	+	1023	WP_042465866.1	LLM class flavin-dependent oxidoreductase	-
A6W98_RS19855	58733..58993	+	261	WP_042465868.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A6W98_RS19860	58993..59394	+	402	WP_042465871.1	type II toxin-antitoxin system VapC family toxin	Toxin
A6W98_RS19865	59405..60598	-	1194	WP_042465873.1	replication initiation protein	-
A6W98_RS19870	61193..62596	+	1404	WP_042465875.1	AAA family ATPase	-
A6W98_RS19875	62598..63692	+	1095	WP_042465877.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102180	102180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14731.89 Da
• Isoelectric Point: 5.1875

>T63062 WP_042465871.1 NZ_CP015420:58993-59394 [Rhodovulum sulfidophilum DSM 1374]
MYLIDTNVISAVRRPDRAPQVRAWLAARPEPELFLSVITLGEIERGIRQQETRDPGFARDLRVWLDRTMLVFADRLLPFG
AAEARIWGRLSAEIGHPGADLMIAATALQHGATVVTGNVSDFEPTGVPIENPF

Nucleotide

• Length: 402 bp

>T63062 NZ_CP015420:58993-59394 [Rhodovulum sulfidophilum DSM 1374]
ATGTATCTGATCGATACCAACGTCATTTCCGCGGTGCGCCGTCCCGACCGCGCGCCGCAGGTCCGCGCCTGGCTGGCCGC
GCGGCCCGAGCCCGAGCTGTTTCTCAGCGTCATCACCCTGGGCGAGATCGAGCGCGGCATCCGCCAGCAGGAGACCCGCG
ACCCCGGTTTCGCCCGCGACCTGCGGGTCTGGCTCGACCGGACCATGCTGGTCTTTGCCGACCGGCTGCTGCCCTTCGGC
GCCGCCGAGGCGCGGATCTGGGGCCGGCTTTCGGCCGAGATCGGCCATCCCGGCGCCGACCTGATGATCGCGGCAACCGC
GCTTCAGCACGGCGCCACCGTGGTCACCGGCAATGTCTCGGATTTCGAACCGACCGGGGTCCCGATCGAGAACCCGTTCT
GA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9363.74 Da
• Isoelectric Point: 10.0776

>AT63062 WP_042465868.1 NZ_CP015420:58733-58993 [Rhodovulum sulfidophilum DSM 1374]
MWTLQDAKNRFSAVVEAALAGVPQEVTRRGKPAVVVLSADDYRRLLKGAAAARESFAEHLMAFPAPEIEAASGIGRAEVR
PRDVRF

Nucleotide

• Length: 261 bp

>AT63062 NZ_CP015420:58733-58993 [Rhodovulum sulfidophilum DSM 1374]
ATGTGGACATTGCAGGATGCCAAGAACCGGTTCAGCGCGGTCGTCGAGGCGGCTCTGGCCGGGGTGCCCCAGGAAGTCAC
CCGCCGCGGCAAGCCCGCGGTCGTGGTGCTGTCGGCCGATGACTACCGGCGCCTGCTGAAAGGCGCCGCCGCCGCCCGCG
AAAGCTTTGCCGAGCATCTCATGGCCTTCCCTGCCCCCGAAATAGAGGCTGCCTCCGGGATCGGCCGCGCCGAGGTCCGC
CCGCGCGACGTCCGCTTCTGA

Structures

Toxin

• AlphaFold DB: A0A0D6B8Q0