Detailed information of TA system TA063060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3118667..3119261
• Replicon: chromosome
• Accession: NZ_CP015418
• Organism: Rhodovulum sulfidophilum DSM 1374

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A6W98_RS14640
• Protein ID: WP_211138697.1
• Coordinates: 3119076..3119261 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A160E2U9
• Locus tag: A6W98_RS14635
• Protein ID: WP_042461682.1
• Coordinates: 3118667..3119059 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6W98_RS14605	3114761..3115168	+	408	Protein_2967	hypothetical protein	-
A6W98_RS14610	3115190..3115828	-	639	WP_063491318.1	hypothetical protein	-
A6W98_RS14615	3115878..3116348	+	471	Protein_2969	phage terminase large subunit family protein	-
A6W98_RS21195	3116370..3116843	-	474	Protein_2970	tetratricopeptide repeat protein	-
A6W98_RS21525	3116749..3117579	-	831	WP_042462605.1	hypothetical protein	-
A6W98_RS21205	3117706..3117840	+	135	Protein_2972	transposase	-
A6W98_RS14625	3117921..3118142	-	222	WP_042462606.1	zinc finger-like domain-containing protein	-
A6W98_RS14630	3118142..3118411	-	270	Protein_2974	hypothetical protein	-
A6W98_RS14635	3118667..3119059	-	393	WP_042461682.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6W98_RS14640	3119076..3119261	-	186	WP_211138697.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6W98_RS14645	3119355..3119879	+	525	WP_063491320.1	hypothetical protein	-
A6W98_RS14650	3119879..3120286	+	408	WP_042462612.1	hypothetical protein	-
A6W98_RS14655	3120271..3121185	+	915	WP_155734824.1	hypothetical protein	-
A6W98_RS14660	3121892..3122353	+	462	WP_042462616.1	SAM-dependent methyltransferase	-
A6W98_RS14665	3122350..3123396	+	1047	WP_196760188.1	iron ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3113328..3128915	15587

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7081.31 Da
• Isoelectric Point: 11.0108

>T63060 WP_211138697.1 NZ_CP015418:c3119261-3119076 [Rhodovulum sulfidophilum DSM 1374]
MLETNSRKIVKRLEQDGFELVKVTGSHHKFRKGDRIVTIPHPKKDLPIGTVRNIYKQAGWL

Nucleotide

• Length: 186 bp

>T63060 NZ_CP015418:c3119261-3119076 [Rhodovulum sulfidophilum DSM 1374]
ATGCTGGAGACCAACAGCCGCAAGATCGTCAAGCGTCTCGAGCAAGACGGCTTCGAGCTGGTGAAGGTCACCGGGTCGCA
CCACAAGTTTCGCAAGGGCGACAGGATCGTGACGATCCCCCACCCGAAGAAGGACCTGCCCATCGGCACGGTCCGCAACA
TCTACAAACAGGCCGGTTGGCTGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13935.68 Da
• Isoelectric Point: 4.4135

>AT63060 WP_042461682.1 NZ_CP015418:c3119059-3118667 [Rhodovulum sulfidophilum DSM 1374]
MRHYIGVVHQEDDSAFGIHFPDVPGCFSAADALDDLLANASEALALHLEDEILPEARSLDAVRADSDVARDLEAGAFLLA
VPFFRLSGRTAKANITMDAGLLAAIDQTAKERGLTRSAFLADLARREITG

Nucleotide

• Length: 393 bp

>AT63060 NZ_CP015418:c3119059-3118667 [Rhodovulum sulfidophilum DSM 1374]
ATGCGTCACTACATCGGCGTCGTGCACCAGGAAGACGACAGCGCCTTCGGCATCCATTTCCCCGACGTGCCCGGCTGCTT
CTCGGCGGCCGATGCCCTCGACGATCTTCTGGCCAATGCCAGCGAGGCGCTCGCGCTTCATCTCGAGGACGAGATCCTGC
CCGAGGCGCGCAGCCTCGATGCCGTTCGGGCCGATAGCGACGTGGCCCGTGACCTCGAGGCCGGGGCGTTCCTTCTGGCG
GTGCCGTTCTTCCGGCTGAGCGGGCGAACCGCCAAGGCGAATATCACCATGGATGCGGGGCTGCTGGCGGCCATCGACCA
GACGGCGAAAGAGCGCGGGCTGACCCGCTCGGCCTTCCTGGCCGATCTGGCGCGGCGCGAGATCACCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A160E2U9