Detailed information of TA system TA063059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2474237..2474831
• Replicon: chromosome
• Accession: NZ_CP015418
• Organism: Rhodovulum sulfidophilum DSM 1374

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A6W98_RS11695
• Protein ID: WP_211138697.1
• Coordinates: 2474237..2474422 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A160E2U9
• Locus tag: A6W98_RS11700
• Protein ID: WP_042461682.1
• Coordinates: 2474439..2474831 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6W98_RS11670	2469452..2469739	-	288	WP_042461673.1	hypothetical protein	-
A6W98_RS11675	2469774..2470583	-	810	WP_042462587.1	hypothetical protein	-
A6W98_RS11680	2470591..2473230	-	2640	WP_063490916.1	hypothetical protein	-
A6W98_RS11685	2473215..2473622	-	408	WP_042461678.1	hypothetical protein	-
A6W98_RS11690	2473619..2474143	-	525	WP_042461680.1	hypothetical protein	-
A6W98_RS11695	2474237..2474422	+	186	WP_211138697.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6W98_RS11700	2474439..2474831	+	393	WP_042461682.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6W98_RS11705	2474840..2475430	-	591	WP_063490917.1	hypothetical protein	-
A6W98_RS11710	2475430..2476113	-	684	WP_052678017.1	hypothetical protein	-
A6W98_RS11715	2476091..2476642	+	552	Protein_2378	hypothetical protein	-
A6W98_RS11720	2476642..2476932	+	291	WP_042461688.1	hypothetical protein	-
A6W98_RS11725	2477080..2478219	+	1140	WP_042461690.1	hypothetical protein	-
A6W98_RS11730	2478819..2479283	+	465	WP_042461692.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2442098..2530909	88811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7081.31 Da
• Isoelectric Point: 11.0108

>T63059 WP_211138697.1 NZ_CP015418:2474237-2474422 [Rhodovulum sulfidophilum DSM 1374]
MLETNSRKIVKRLEQDGFELVKVTGSHHKFRKGDRIVTIPHPKKDLPIGTVRNIYKQAGWL

Nucleotide

• Length: 186 bp

>T63059 NZ_CP015418:2474237-2474422 [Rhodovulum sulfidophilum DSM 1374]
ATGCTGGAGACCAACAGCCGCAAGATCGTCAAGCGTCTCGAGCAAGACGGCTTCGAGCTGGTGAAGGTCACCGGGTCGCA
CCACAAGTTTCGCAAGGGCGACAGGATCGTGACGATCCCCCACCCGAAGAAGGACCTGCCCATCGGCACGGTCCGCAACA
TCTACAAACAGGCCGGTTGGCTGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13935.68 Da
• Isoelectric Point: 4.4135

>AT63059 WP_042461682.1 NZ_CP015418:2474439-2474831 [Rhodovulum sulfidophilum DSM 1374]
MRHYIGVVHQEDDSAFGIHFPDVPGCFSAADALDDLLANASEALALHLEDEILPEARSLDAVRADSDVARDLEAGAFLLA
VPFFRLSGRTAKANITMDAGLLAAIDQTAKERGLTRSAFLADLARREITG

Nucleotide

• Length: 393 bp

>AT63059 NZ_CP015418:2474439-2474831 [Rhodovulum sulfidophilum DSM 1374]
ATGCGTCACTACATCGGCGTCGTGCACCAGGAAGACGACAGCGCCTTCGGCATCCATTTCCCCGACGTGCCCGGCTGCTT
CTCGGCCGCCGATGCGCTCGACGATCTTCTGGCCAATGCCAGCGAGGCGCTCGCGCTTCATCTCGAGGACGAGATCCTGC
CCGAGGCGCGCAGCCTCGATGCCGTTCGGGCCGACAGCGACGTGGCCCGTGACCTCGAGGCCGGGGCGTTCCTTCTGGCG
GTGCCGTTCTTCCGGCTGAGCGGGCGAACCGCCAAGGCGAATATCACCATGGATGCGGGGCTGCTGGCGGCCATCGACCA
GACGGCGAAAGAGCGCGGGCTGACCCGCTCGGCCTTCCTGGCCGATCTGGCGCGGCGCGAGATCACCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A160E2U9