Detailed information of TA system TA063058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 738695..739282
• Replicon: chromosome
• Accession: NZ_CP015418
• Organism: Rhodovulum sulfidophilum DSM 1374

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: A6W98_RS03670
• Protein ID: WP_042464486.1
• Coordinates: 738992..739282 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: A6W98_RS03665
• Protein ID: WP_042458069.1
• Coordinates: 738695..738982 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6W98_RS03650	734181..734870	+	690	WP_042458062.1	hypothetical protein	-
A6W98_RS21635	735114..737978	-	2865	WP_063490869.1	pentapeptide repeat-containing protein	-
A6W98_RS03665	738695..738982	-	288	WP_042458069.1	putative addiction module antidote protein	Antitoxin
A6W98_RS03670	738992..739282	-	291	WP_042464486.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6W98_RS03675	739662..740468	+	807	WP_155734706.1	HNH endonuclease	-
A6W98_RS21430	740834..740986	+	153	WP_168161804.1	hypothetical protein	-
A6W98_RS03685	740986..742254	+	1269	WP_042458072.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
A6W98_RS03690	742251..742727	+	477	WP_042458075.1	DUF2948 family protein	-
A6W98_RS03695	742813..744123	+	1311	WP_042458078.1	histidinol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	724420..756446	32026

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10994.80 Da
• Isoelectric Point: 10.2250

>T63058 WP_042464486.1 NZ_CP015418:c739282-738992 [Rhodovulum sulfidophilum DSM 1374]
MRYEIHQSAEFSKWLRKLKDRTAQARIAIRIARLEAGLMGDAKFFDGIGELRITYGPGYRVYFVQQGETIIILLCGGDKG
SQRRDIEKAKTMAKEL

Nucleotide

• Length: 291 bp

>T63058 NZ_CP015418:c739282-738992 [Rhodovulum sulfidophilum DSM 1374]
ATGCGTTACGAAATTCACCAGTCCGCCGAGTTCTCGAAATGGCTTCGCAAGCTGAAAGACCGCACGGCGCAAGCCCGCAT
CGCGATCAGGATCGCCCGGCTTGAAGCTGGCCTCATGGGCGACGCCAAGTTCTTCGACGGCATCGGTGAACTTCGGATCA
CCTACGGCCCGGGATACCGCGTCTACTTCGTCCAGCAGGGCGAGACGATCATCATCCTGCTCTGCGGCGGCGACAAAGGC
TCCCAGCGCCGGGACATCGAAAAGGCCAAGACCATGGCCAAGGAACTTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10051.47 Da
• Isoelectric Point: 5.6939

>AT63058 WP_042458069.1 NZ_CP015418:c738982-738695 [Rhodovulum sulfidophilum DSM 1374]
MPIETTRFDAAEYLDTPEAQAMLLSDAFETGDAAYIKHAIGIVARARGIKDTAEAAGITREALHRALGEKGNPRLSTILG
VTRALGLTLKVEASA

Nucleotide

• Length: 288 bp

>AT63058 NZ_CP015418:c738982-738695 [Rhodovulum sulfidophilum DSM 1374]
ATGCCTATCGAAACTACCCGCTTCGACGCGGCCGAATATCTCGACACGCCGGAAGCGCAAGCCATGCTGCTCTCCGACGC
CTTCGAGACGGGTGACGCCGCCTACATCAAGCACGCCATCGGGATCGTCGCCAGGGCGCGCGGGATCAAGGACACGGCCG
AGGCCGCCGGGATCACGCGGGAGGCGCTGCACCGCGCCTTGGGTGAGAAGGGAAACCCGAGGCTGTCTACTATCCTCGGC
GTGACCAGGGCACTCGGGCTGACCTTGAAGGTCGAGGCGTCGGCCTGA