63054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1085805..1086387 Replicon chromosome
Accession NZ_CP015410
Organism Enterococcus faecalis strain KB1

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag A4V06_RS05360 Protein ID WP_002355414.1
Coordinates 1086079..1086387 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag A4V06_RS05355 Protein ID WP_002326825.1
Coordinates 1085805..1086077 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4V06_RS05330 1081024..1081425 - 402 WP_065535981.1 sigma-70 family RNA polymerase sigma factor -
A4V06_RS05345 1084648..1085502 + 855 WP_065535983.1 ParA family protein -
A4V06_RS05350 1085573..1085788 + 216 WP_002355411.1 peptide-binding protein -
A4V06_RS05355 1085805..1086077 + 273 WP_002326825.1 antitoxin Antitoxin
A4V06_RS05360 1086079..1086387 + 309 WP_002355414.1 zeta toxin family protein Toxin
A4V06_RS05365 1086467..1086895 - 429 WP_071623404.1 tyrosine-type recombinase/integrase -
A4V06_RS05370 1086940..1087440 - 501 WP_002355415.1 HAD family hydrolase -
A4V06_RS05375 1087445..1088212 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
A4V06_RS05385 1088700..1089125 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
A4V06_RS05390 1089142..1089657 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
A4V06_RS05395 1089668..1090600 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T63054 WP_002355414.1 NZ_CP015410:1086079-1086387 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T63054 NZ_CP015410:1086079-1086387 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT63054 WP_002326825.1 NZ_CP015410:1085805-1086077 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT63054 NZ_CP015410:1085805-1086077 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References