Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 907160..907761 Replicon chromosome
Accession NZ_CP015410
Organism Enterococcus faecalis strain KB1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag A4V06_RS04415 Protein ID WP_065535946.1
Coordinates 907160..907504 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag A4V06_RS04420 Protein ID WP_065535947.1
Coordinates 907498..907761 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4V06_RS04370 902173..902598 - 426 WP_065535939.1 hypothetical protein -
A4V06_RS04375 902588..902860 - 273 WP_065535940.1 hypothetical protein -
A4V06_RS04380 902861..903130 - 270 WP_065535941.1 DUF2089 family protein -
A4V06_RS04385 903347..903478 - 132 WP_065535942.1 enterocin L50 family leaderless bacteriocin -
A4V06_RS04390 903498..903632 - 135 WP_061101451.1 enterocin L50 family leaderless bacteriocin -
A4V06_RS04400 904315..904959 - 645 WP_198158935.1 C39 family peptidase -
A4V06_RS04405 905017..906048 - 1032 WP_065535945.1 M23 family metallopeptidase -
A4V06_RS04410 906630..907033 + 404 Protein_817 hypothetical protein -
A4V06_RS04415 907160..907504 - 345 WP_065535946.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A4V06_RS04420 907498..907761 - 264 WP_065535947.1 PbsX family transcriptional regulator Antitoxin
A4V06_RS04425 907870..909372 - 1503 Protein_820 relaxase/mobilization nuclease domain-containing protein -
A4V06_RS04430 910492..911736 - 1245 WP_089413444.1 aminoacyltransferase -
A4V06_RS15155 912447..912602 - 156 WP_157108316.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element lsa(A) esp / prgB/asc10 / esp 830811..988092 157281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12831.88 Da        Isoelectric Point: 9.3343

>T63050 WP_065535946.1 NZ_CP015410:c907504-907160 [Enterococcus faecalis]
MVKVPRQGDILLLNTAPRSGHEQTGKRPYIVLSHNIIADYSNVVIVAPISSTNRNYPLYVSIDSSYQMKTSGKVLLDQLT
TIDYEARKCVFLETAHENLVNELLLKVKAVFQKV

Download         Length: 345 bp

>T63050 NZ_CP015410:c907504-907160 [Enterococcus faecalis]
ATGGTAAAAGTTCCACGCCAAGGCGATATTTTATTATTGAATACAGCTCCCCGATCAGGTCATGAACAGACAGGAAAGAG
ACCGTATATTGTTTTAAGTCACAATATTATTGCGGATTACAGTAATGTTGTCATTGTTGCTCCAATATCAAGCACCAATA
GAAACTATCCTCTGTATGTTTCTATTGACTCTTCCTATCAAATGAAAACTTCAGGAAAAGTATTGTTAGATCAATTAACA
ACTATTGATTACGAAGCTAGAAAATGTGTATTTCTAGAGACAGCTCATGAAAACCTAGTCAATGAACTATTATTAAAGGT
TAAAGCGGTATTTCAAAAAGTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9844.17 Da        Isoelectric Point: 5.1255

>AT63050 WP_065535947.1 NZ_CP015410:c907761-907498 [Enterococcus faecalis]
MEMLSIKKWGNSNGLRLPKSTMEYLQLHTEDKVKVIQDESDGKKRLIIEAVDSNDELTIEQLFANYNGGKVHVAVQNLGE
AVGNEKW

Download         Length: 264 bp

>AT63050 NZ_CP015410:c907761-907498 [Enterococcus faecalis]
ATGGAAATGTTATCGATAAAAAAATGGGGAAATAGTAATGGACTTAGACTTCCTAAATCTACGATGGAATATCTTCAACT
CCATACAGAAGACAAAGTGAAGGTTATACAAGATGAATCTGATGGTAAGAAACGATTAATTATCGAAGCTGTAGATTCAA
ATGATGAATTAACAATTGAACAATTGTTTGCAAACTACAACGGAGGAAAAGTACATGTAGCTGTTCAAAATTTAGGAGAA
GCCGTGGGGAATGAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References