Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4866475..4866991 Replicon chromosome
Accession NZ_CP015392
Organism Klebsiella pneumoniae strain CR14

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag A6P37_RS24240 Protein ID WP_002886902.1
Coordinates 4866475..4866759 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A6P37_RS24245 Protein ID WP_002886901.1
Coordinates 4866749..4866991 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P37_RS24220 4861959..4862267 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
A6P37_RS32105 4862352..4862525 + 174 WP_002886906.1 hypothetical protein -
A6P37_RS24225 4862528..4863271 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A6P37_RS24230 4863628..4865766 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
A6P37_RS24235 4866007..4866471 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A6P37_RS24240 4866475..4866759 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6P37_RS24245 4866749..4866991 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6P37_RS24250 4867069..4868979 - 1911 WP_004152270.1 BglG family transcription antiterminator -
A6P37_RS24255 4869002..4870156 - 1155 WP_002886900.1 lactonase family protein -
A6P37_RS24260 4870222..4870962 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T63031 WP_002886902.1 NZ_CP015392:c4866759-4866475 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T63031 NZ_CP015392:c4866759-4866475 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT63031 WP_002886901.1 NZ_CP015392:c4866991-4866749 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT63031 NZ_CP015392:c4866991-4866749 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References