Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4790709..4791225 Replicon chromosome
Accession NZ_CP015385
Organism Klebsiella pneumoniae strain NY9

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag A6P56_RS25215 Protein ID WP_002886902.1
Coordinates 4790709..4790993 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A6P56_RS25220 Protein ID WP_002886901.1
Coordinates 4790983..4791225 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P56_RS25185 4786193..4786501 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
A6P56_RS33960 4786586..4786759 + 174 WP_002886906.1 hypothetical protein -
A6P56_RS25195 4786762..4787505 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A6P56_RS25205 4787862..4790000 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
A6P56_RS25210 4790241..4790705 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A6P56_RS25215 4790709..4790993 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6P56_RS25220 4790983..4791225 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6P56_RS25225 4791303..4793213 - 1911 WP_004152270.1 BglG family transcription antiterminator -
A6P56_RS25230 4793236..4794390 - 1155 WP_002886900.1 lactonase family protein -
A6P56_RS25235 4794456..4795196 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T63006 WP_002886902.1 NZ_CP015385:c4790993-4790709 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T63006 NZ_CP015385:c4790993-4790709 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT63006 WP_002886901.1 NZ_CP015385:c4791225-4790983 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT63006 NZ_CP015385:c4791225-4790983 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References