Detailed information of TA system TA062971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 3730819..3731381
• Replicon: chromosome
• Accession: NZ_CP015381
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: S7UUL9
• Locus tag: dmul_RS16270
• Protein ID: WP_020877879.1
• Coordinates: 3731016..3731381 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: dmul_RS16265
• Protein ID: WP_040416134.1
• Coordinates: 3730819..3731013 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dmul_RS16245	3726626..3726928	+	303	WP_020877875.1	hypothetical protein	-
dmul_RS16250	3726987..3727487	-	501	WP_020877876.1	DUF255 domain-containing protein	-
dmul_RS16255	3727681..3729525	-	1845	WP_144016391.1	thioredoxin family protein	-
dmul_RS16260	3729565..3730416	-	852	WP_020877878.1	pyrroline-5-carboxylate reductase	-
dmul_RS16265	3730819..3731013	+	195	WP_040416134.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
dmul_RS16270	3731016..3731381	+	366	WP_020877879.1	PIN domain-containing protein	Toxin
dmul_RS16275	3731486..3732319	+	834	WP_020877880.1	hypothetical protein	-
dmul_RS16280	3732319..3732612	+	294	WP_040416137.1	hypothetical protein	-
dmul_RS16285	3732642..3732941	+	300	WP_020877882.1	YggT family protein	-
dmul_RS16290	3732998..3734080	+	1083	WP_020877883.1	type IV pilus twitching motility protein PilT	-
dmul_RS16295	3734104..3735258	+	1155	WP_020877884.1	PilT/PilU family type 4a pilus ATPase	-
dmul_RS16300	3735255..3735932	+	678	WP_020877885.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13361.66 Da
• Isoelectric Point: 5.0870

>T62971 WP_020877879.1 NZ_CP015381:3731016-3731381 [Desulfococcus multivorans]
MILADTNVWIKHFRESDAELIEHLNMGFVACHPFIIGELACGNIGNRAEILTLLKALPAAPIVEPRELLNFIENNMLMGR
GLGYVDIQILASAIIGNVVLWTFDRRLNAAATELGVSYLKS

Nucleotide

• Length: 366 bp

>T62971 NZ_CP015381:3731016-3731381 [Desulfococcus multivorans]
ATGATTCTTGCCGATACCAACGTTTGGATCAAACATTTCAGAGAGTCCGATGCTGAACTCATTGAGCATTTGAACATGGG
TTTTGTGGCATGCCACCCGTTTATTATCGGTGAATTGGCCTGCGGCAATATAGGGAATCGGGCGGAAATTCTGACGCTCC
TCAAGGCGCTGCCCGCCGCACCCATTGTTGAACCGAGAGAACTTTTGAATTTTATAGAAAATAACATGCTGATGGGGCGC
GGTCTCGGCTACGTGGATATTCAGATACTGGCTTCCGCGATTATCGGTAACGTCGTACTATGGACTTTTGATCGTCGTCT
GAATGCGGCGGCAACGGAGTTGGGCGTTTCATATTTGAAAAGCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7244.35 Da
• Isoelectric Point: 10.7279

>AT62971 WP_040416134.1 NZ_CP015381:3730819-3731013 [Desulfococcus multivorans]
VRTTLNIEDDLIERASDLTGIKEKTALVRKGLEALISLESSRRLAALGGTEKDLRMPRRRRPEQ

Nucleotide

• Length: 195 bp

>AT62971 NZ_CP015381:3730819-3731013 [Desulfococcus multivorans]
GTGAGAACAACATTGAACATCGAGGACGACCTCATCGAAAGAGCGTCGGACCTTACCGGAATAAAAGAAAAAACAGCTCT
TGTCCGCAAAGGACTCGAAGCCCTGATCAGTTTGGAGAGCAGCAGGCGCCTGGCTGCACTGGGTGGAACCGAGAAAGATC
TCCGGATGCCAAGGCGAAGACGACCGGAGCAATAA

Structures

Toxin

• AlphaFold DB: S7UUL9