Detailed information of TA system TA062969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1829869..1830483
• Replicon: chromosome
• Accession: NZ_CP015381
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: dmul_RS19700
• Protein ID: WP_078081235.1
• Coordinates: 1830295..1830483 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S7V914
• Locus tag: dmul_RS07905
• Protein ID: WP_020875557.1
• Coordinates: 1829869..1830285 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dmul_RS19685	1824892..1825479	+	588	Protein_1545	hypothetical protein	-
dmul_RS07880	1825581..1826069	+	489	WP_020875552.1	GNAT family N-acetyltransferase	-
dmul_RS19690	1826142..1826663	+	522	WP_020875553.1	AAA family ATPase	-
dmul_RS07885	1826683..1826895	+	213	WP_020875554.1	PH domain-containing protein	-
dmul_RS07890	1826892..1828205	+	1314	WP_020875555.1	cation:proton antiporter	-
dmul_RS07895	1828426..1828878	+	453	WP_078081234.1	RidA family protein	-
dmul_RS07900	1828888..1829733	+	846	WP_020875556.1	PhzF family phenazine biosynthesis protein	-
dmul_RS07905	1829869..1830285	-	417	WP_020875557.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
dmul_RS19700	1830295..1830483	-	189	WP_078081235.1	type II toxin-antitoxin system HicA family toxin	Toxin
dmul_RS07910	1830630..1831769	+	1140	WP_020875558.1	NADH:flavin oxidoreductase	-
dmul_RS07915	1831889..1832131	+	243	WP_020875559.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
dmul_RS07920	1832125..1832391	+	267	WP_040414299.1	Txe/YoeB family addiction module toxin	-
dmul_RS07925	1832660..1832974	-	315	WP_020875561.1	HigA family addiction module antidote protein	-
dmul_RS19705	1832986..1833267	-	282	WP_078081377.1	type II toxin-antitoxin system RelE/ParE family toxin	-
dmul_RS07930	1833628..1834113	+	486	WP_020875562.1	DUF1772 domain-containing protein	-
dmul_RS07935	1834417..1835040	+	624	WP_040414325.1	hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-125)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7153.33 Da
• Isoelectric Point: 11.0174

>T62969 WP_078081235.1 NZ_CP015381:c1830483-1830295 [Desulfococcus multivorans]
MDSRKIIQILKQNGWYEIAKVGSHTQFRHPQKKGRVTVPHPEKDIPIGTLKSIERQSGIKFT

Nucleotide

• Length: 189 bp

>T62969 NZ_CP015381:c1830483-1830295 [Desulfococcus multivorans]
ATGGACAGCCGGAAAATCATTCAGATACTCAAACAGAACGGCTGGTATGAGATCGCCAAAGTTGGCTCTCATACACAATT
CCGGCATCCACAAAAAAAGGGACGCGTAACCGTACCACACCCTGAAAAGGATATACCGATCGGCACATTAAAGAGTATCG
AGCGCCAGTCGGGAATTAAGTTCACGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14879.96 Da
• Isoelectric Point: 5.1473

>AT62969 WP_020875557.1 NZ_CP015381:c1830285-1829869 [Desulfococcus multivorans]
MANYIAVVHKASKTDFGVSFPDFPGCITAGQTVDEAKDLAQEALALHVKGMIEDGDEMPAPSKLEDIMADADYADVIAYL
VVSIPDTKPRTVRINITVPEMTLKQIDAAAKKRGMSRSSFLVHLAQNAIHSDHSQPSA

Nucleotide

• Length: 417 bp

>AT62969 NZ_CP015381:c1830285-1829869 [Desulfococcus multivorans]
ATGGCAAATTATATAGCTGTCGTTCATAAAGCGTCCAAAACTGACTTTGGCGTATCTTTTCCAGATTTTCCGGGTTGTAT
TACCGCTGGGCAAACCGTGGACGAAGCCAAGGATTTAGCCCAAGAGGCGCTTGCACTCCATGTTAAAGGAATGATTGAAG
ACGGCGATGAAATGCCGGCTCCATCCAAACTCGAAGATATAATGGCTGATGCGGACTACGCTGATGTCATCGCTTATCTG
GTAGTTTCTATTCCGGATACCAAACCTCGCACCGTAAGGATCAATATTACCGTGCCAGAGATGACCCTTAAGCAAATTGA
TGCAGCAGCCAAAAAAAGGGGAATGTCAAGATCCTCCTTTCTCGTTCATCTCGCGCAGAACGCGATTCATTCAGATCATT
CTCAACCATCGGCATAG

Structures

Antitoxin

• AlphaFold DB: S7V914