Detailed information of TA system TA062968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 492025..492458
• Replicon: chromosome
• Accession: NZ_CP015381
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: dmul_RS19585
• Protein ID: WP_078081173.1
• Coordinates: 492234..492458 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: dmul_RS02090
• Protein ID: WP_040416853.1
• Coordinates: 492025..492237 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dmul_RS20000	490316..490513	+	198	WP_040416847.1	hypothetical protein	-
dmul_RS19580	490606..490860	+	255	WP_078081172.1	type II toxin-antitoxin system HicB family antitoxin	-
dmul_RS02085	490983..491822	+	840	WP_040416850.1	class I SAM-dependent methyltransferase	-
dmul_RS02090	492025..492237	+	213	WP_040416853.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
dmul_RS19585	492234..492458	+	225	WP_078081173.1	type II toxin-antitoxin system HicA family toxin	Toxin
dmul_RS02095	492589..492777	+	189	WP_020878760.1	hypothetical protein	-
dmul_RS02100	492796..493566	+	771	WP_020878761.1	MBL fold metallo-hydrolase	-
dmul_RS02105	494330..494593	+	264	WP_020878762.1	hypothetical protein	-
dmul_RS02110	494784..496310	-	1527	WP_040416863.1	phospholipase D family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-60)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8017.40 Da
• Isoelectric Point: 11.2875

>T62968 WP_078081173.1 NZ_CP015381:492234-492458 [Desulfococcus multivorans]
VSKLPKISGKAAVSALSKIGYGIDHQTGSHMILRQSAPPNRRLTIPNHKELATGTLRAIIRQAGLTVEEFMNLL

Nucleotide

• Length: 225 bp

>T62968 NZ_CP015381:492234-492458 [Desulfococcus multivorans]
GTGAGCAAGCTACCCAAAATATCCGGAAAAGCAGCGGTGTCTGCATTGTCAAAAATCGGATATGGAATCGATCATCAAAC
AGGAAGCCACATGATACTTAGGCAATCTGCTCCGCCAAATCGACGGCTCACAATACCCAATCACAAAGAATTGGCAACAG
GTACACTACGGGCAATAATCAGGCAAGCTGGGTTAACAGTCGAAGAGTTCATGAATCTGCTTTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7745.90 Da
• Isoelectric Point: 4.1364

>AT62968 WP_040416853.1 NZ_CP015381:492025-492237 [Desulfococcus multivorans]
MKFRIIIEQDEDGMFVAEVPALPGCISQGTTREESLTNIKDAIIGYLESLKKHGDPIPPSIYEEVIEVAV

Nucleotide

• Length: 213 bp

>AT62968 NZ_CP015381:492025-492237 [Desulfococcus multivorans]
ATGAAGTTTAGAATTATTATTGAACAAGATGAAGATGGGATGTTTGTGGCTGAAGTTCCTGCCTTGCCGGGTTGTATTTC
CCAAGGCACCACGCGAGAAGAATCGCTTACAAATATAAAAGATGCCATTATCGGATATTTGGAAAGTTTGAAAAAGCATG
GAGATCCGATACCCCCGTCAATATACGAAGAGGTAATCGAGGTAGCGGTGTGA