Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 37660..38210 Replicon plasmid unnamed
Accession NZ_CP015380
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag A6V27_RS20795 Protein ID WP_040047078.1
Coordinates 37896..38210 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag A6V27_RS20790 Protein ID WP_040047079.1
Coordinates 37660..37893 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS20770 32999..33328 + 330 WP_063587664.1 relaxase domain-containing protein -
A6V27_RS20775 33306..35588 + 2283 WP_081250340.1 AAA family ATPase -
A6V27_RS21315 36258..37268 - 1011 Protein_29 IS110 family transposase -
A6V27_RS20790 37660..37893 + 234 WP_040047079.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
A6V27_RS20795 37896..38210 + 315 WP_040047078.1 CcdB family protein Toxin
A6V27_RS21610 38467..38637 - 171 WP_193764314.1 hypothetical protein -
A6V27_RS20800 38735..39529 + 795 WP_052439989.1 lysine exporter LysO family protein -
A6V27_RS20805 39687..40466 + 780 WP_040047077.1 MBL fold metallo-hydrolase -
A6V27_RS20810 40595..41569 + 975 WP_040047076.1 helix-turn-helix domain-containing protein -
A6V27_RS21615 41961..42839 - 879 Protein_36 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87576 87576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(7-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11594.73 Da        Isoelectric Point: 8.9696

>T62967 WP_040047078.1 NZ_CP015380:37896-38210 [Hafnia alvei]
MQFTVYRGIGKNAAFPLLIDITSDIIGDINRRLVIPLMPVERFGHHRPPERLNPVLDMTDGKKYVLMTHEAATIPVKALG
VKFCDATAYRVVIKGAVDFMLDGI

Download         Length: 315 bp

>T62967 NZ_CP015380:37896-38210 [Hafnia alvei]
ATGCAATTTACTGTATACCGAGGTATCGGTAAAAACGCGGCTTTCCCATTGTTAATCGATATTACCAGTGACATCATTGG
TGATATTAATCGCCGTCTGGTTATTCCTTTAATGCCTGTGGAACGTTTTGGGCATCATCGGCCACCGGAAAGACTTAACC
CAGTACTGGATATGACTGACGGTAAAAAATACGTATTGATGACTCATGAAGCCGCGACTATTCCGGTAAAAGCGCTTGGT
GTAAAATTTTGTGATGCAACAGCATATAGGGTAGTCATCAAAGGTGCTGTTGACTTCATGTTGGATGGAATCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8552.67 Da        Isoelectric Point: 6.2935

>AT62967 WP_040047079.1 NZ_CP015380:37660-37893 [Hafnia alvei]
MSIKRNKQSVTVTLERSLLSRAREAGVNMSATLAAALDTELKKNAAMRWLEDNAESVAVLNRIGEETGCFSDEYRSF

Download         Length: 234 bp

>AT62967 NZ_CP015380:37660-37893 [Hafnia alvei]
ATGAGCATTAAACGTAATAAACAGAGTGTCACCGTGACTCTGGAACGTAGCCTGCTGTCACGGGCTCGTGAAGCCGGCGT
TAATATGAGCGCTACGTTAGCTGCTGCACTTGATACAGAACTAAAAAAAAATGCAGCGATGCGCTGGCTCGAAGATAACG
CAGAATCTGTTGCTGTACTAAATCGTATTGGGGAAGAAACGGGATGTTTTTCTGACGAGTACCGGAGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References